Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK036823-13
Application #
2139886
Study Section
Nutrition Study Section (NTN)
Project Start
1985-07-01
Project End
1997-11-30
Budget Start
1996-07-01
Budget End
1997-11-30
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Arkansas Children's Hospital Research Institute
Department
Type
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72202
Mock, Donald M; Nalbant, Demet; Kyosseva, Svetlana V et al. (2018) Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced-based analysis and recommendations. Transfusion 58:2068-2081
Bogusiewicz, Anna; Horvath, Thomas D; Stratton, Shawna L et al. (2012) Measurement of acylcarnitine substrate to product ratios specific to biotin-dependent carboxylases offers a combination of indicators of biotin status in humans. J Nutr 142:1621-5
Stratton, Shawna L; Horvath, Thomas D; Bogusiewicz, Anna et al. (2011) Urinary excretion of 3-hydroxyisovaleryl carnitine is an early and sensitive indicator of marginal biotin deficiency in humans. J Nutr 141:353-8
Mock, Donald M (2009) Marginal biotin deficiency is common in normal human pregnancy and is highly teratogenic in mice. J Nutr 139:154-7
Van Hove, Johan L K; Josefsberg, Sagi; Freehauf, Cynthia et al. (2008) Management of a patient with holocarboxylase synthetase deficiency. Mol Genet Metab 95:201-5
Mock, Donald M; Bogusiewicz, Anna (2008) Biotin-protein bond: instability and structural modification to provide stability for in vivo applications. Methods Mol Biol 418:209-20
Bogusiewicz, Anna; Mock, Nell I; Mock, Donald M (2005) A biotin-protein bond with stability in plasma. Anal Biochem 337:98-102
Mock, Donald M (2005) Marginal biotin deficiency is teratogenic in mice and perhaps humans: a review of biotin deficiency during human pregnancy and effects of biotin deficiency on gene expression and enzyme activities in mouse dam and fetus. J Nutr Biochem 16:435-7
Bogusiewicz, Anna; Mock, Nell I; Mock, Donald M (2004) Release of biotin from biotinylated proteins occurs enzymatically and nonenzymatically in human plasma. Anal Biochem 331:260-6
Helm, R M; Mock, N I; Simpson, P et al. (2001) Certain immune markers are not good indicators of mild to moderate biotin deficiency in rats. J Nutr 131:3231-6

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