Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK037273-09
Application #
2140053
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1986-06-01
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Florida
Department
Neurosciences
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Turner, Russell T; Kalra, Satya P; Wong, Carmen P et al. (2013) Peripheral leptin regulates bone formation. J Bone Miner Res 28:22-34
Iwaniec, Urszula T; Boghossian, Stéphane; Trevisiol, Cynthia H et al. (2011) Hypothalamic leptin gene therapy prevents weight gain without long-term detrimental effects on bone in growing and skeletally mature female rats. J Bone Miner Res 26:1506-16
Kalra, S P (2011) Pivotal role of leptin-hypothalamus signaling in the etiology of diabetes uncovered by gene therapy: a new therapeutic intervention? Gene Ther 18:319-25
Jackson, M A; Iwaniec, U T; Turner, R T et al. (2011) Effects of increased hypothalamic leptin gene expression on ovariectomy-induced bone loss in rats. Peptides 32:1575-80
Kalra, Satya P; Kalra, Pushpa S (2010) Neuroendocrine control of energy homeostasis: update on new insights. Prog Brain Res 181:17-33
Kalra, Satya P; Dube, Michael G; Iwaniec, Urszula T (2009) Leptin increases osteoblast-specific osteocalcin release through a hypothalamic relay. Peptides 30:967-73
Kojima, Shinya; Asakawa, Akihiro; Amitani, Haruka et al. (2009) Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice. Peptides 30:962-6
Kalra, Satya P (2009) Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; a benefit beyond weight and appetite regulation. Peptides 30:1957-63
Iwaniec, U T; Dube, M G; Boghossian, S et al. (2009) Body mass influences cortical bone mass independent of leptin signaling. Bone 44:404-12
Kalra, Satya P (2008) Disruption in the leptin-NPY link underlies the pandemic of diabetes and metabolic syndrome: new therapeutic approaches. Nutrition 24:820-6

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