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Huo, Jianxin; Luo, Rui-Hua; Metz, Stewart A et al. (2002) Activation of caspase-2 mediates the apoptosis induced by GTP-depletion in insulin-secreting (HIT-T15) cells. Endocrinology 143:1695-704
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Metz, S; Holland, S; Johnson, L et al. (2001) Inosine-5'-monophosphate dehydrogenase is required for mitogenic competence of transformed pancreatic beta cells. Endocrinology 142:193-204
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Li, G D; Luo, R H; Metz, S A (2000) Effects of inhibitors of guanine nucleotide synthesis on membrane potential and cytosolic free Ca2+ levels in insulin-secreting cells. Biochem Pharmacol 59:545-56
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Metz, S A; Meredith, M; Vadakekalam, J et al. (1999) A defect late in stimulus-secretion coupling impairs insulin secretion in Goto-Kakizaki diabetic rats. Diabetes 48:1754-62
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Li, G; Segu, V B; Rabaglia, M E et al. (1998) Prolonged depletion of guanosine triphosphate induces death of insulin-secreting cells by apoptosis. Endocrinology 139:3752-62
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Segu, V B; Li, G; Metz, S A (1998) Use of a soluble tetrazolium compound to assay metabolic activation of intact beta cells. Metabolism 47:824-30
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Vadakekalam, J; Metz, S (1998) Isotopic efflux studies as indices of phospholipase activation. Methods Mol Biol 105:175-85
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Kowluru, A; Metz, S A (1998) Purine nucleotide- and sugar phosphate-induced inhibition of the carboxyl methylation and catalysis of protein phosphatase-2A in insulin-secreting cells: protection by divalent cations. Biosci Rep 18:171-86
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Vadakekalam, J; Rabaglia, M E; Metz, S A (1997) Roles of GTP and phospholipase C in the potentiation of Ca(2+)-induced insulin secretion by glucose in rat pancreatic islets. J Endocrinol 153:61-71
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Kowluru, A; Metz, S A (1997) Ceramide-activated protein phosphatase-2A activity in insulin-secreting cells. FEBS Lett 418:179-82
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