Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
7R01DK038712-15
Application #
6721494
Study Section
Physiological Chemistry Study Section (PC)
Program Officer
Blondel, Olivier
Project Start
1987-07-01
Project End
2006-03-31
Budget Start
2004-04-01
Budget End
2006-03-31
Support Year
15
Fiscal Year
2004
Total Cost
$309,789
Indirect Cost

  Institution

Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Kuznetsova, Alexandra; Yu, Yue; Hollister-Lock, Jennifer et al. (2016) Trimeprazine increases IRS2 in human islets and promotes pancreatic ? cell growth and function in mice. JCI Insight 1:
Copps, Kyle D; Hançer, Nancy J; Qiu, Wei et al. (2016) Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase. J Biol Chem 291:8602-17
Law, Nathan C; White, Morris F; Hunzicker-Dunn, Mary E (2016) G protein-coupled receptors (GPCRs) That Signal via Protein Kinase A (PKA) Cross-talk at Insulin Receptor Substrate 1 (IRS1) to Activate the phosphatidylinositol 3-kinase (PI3K)/AKT Pathway. J Biol Chem 291:27160-27169
Hançer, Nancy J; Qiu, Wei; Cherella, Christine et al. (2014) Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation. J Biol Chem 289:12467-84
Ryu, Jiyoon; Galan, Amanda K; Xin, Xiaoban et al. (2014) APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor. Cell Rep 7:1227-38
Herrema, Hilde; Lee, Jaemin; Zhou, Yingjiang et al. (2014) IRS1Ser³?? phosphorylation does not mediate mTORC1-induced insulin resistance. Biochem Biophys Res Commun 443:689-93
Sadagurski, Marianna; Dong, X Charlie; Myers Jr, Martin G et al. (2014) Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis. Mol Metab 3:55-63
Hookham, Michelle B; O'Donovan, Helen C; Church, Rachel H et al. (2013) Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy. FEBS J 280:3232-43
Park, Kyoungmin; Li, Qian; Rask-Madsen, Christian et al. (2013) Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol Cell Biol 33:3227-41
Rhodes, Christopher J; White, Morris F; Leahy, John L et al. (2013) Direct autocrine action of insulin on ?-cells: does it make physiological sense? Diabetes 62:2157-63

Showing the most recent 10 out of 37 publications