Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK038828-09
Application #
2140690
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1986-09-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
State University New York Stony Brook
Department
Physiology
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Laux, Wolfgang H G; Pande, Praveen; Shoshani, Ilana et al. (2004) Pro-nucleotide inhibitors of adenylyl cyclases in intact cells. J Biol Chem 279:13317-32
Shoshani, I; Taussig, R; Iyengar, R et al. (2000) Synthesis and use of 3'-(azidoiodosalicyl) derivatives of 2', 5'-dideoxyadenosine as photoaffinity ligands for adenylyl cyclase. Arch Biochem Biophys 376:221-8
Tesmer, J J; Dessauer, C W; Sunahara, R K et al. (2000) Molecular basis for P-site inhibition of adenylyl cyclase. Biochemistry 39:14464-71
Shoshani, I; Bianchi, G; Desaubry, L et al. (2000) Lys-Ala mutations of type I adenylyl cyclase result in altered susceptibility to inhibition by adenine nucleoside 3'-polyphosphates. Arch Biochem Biophys 374:389-94
Tesmer, J J; Sunahara, R K; Johnson, R A et al. (1999) Two-metal-Ion catalysis in adenylyl cyclase. Science 285:756-60
Ibrahimi, A; Abumrad, N; Maghareie, H et al. (1999) Adenylyl cyclase P-site ligands accelerate differentiation in Ob1771 preadipocytes. Am J Physiol 276:C487-96
Shoshani, I; Boudou, V; Pierra, C et al. (1999) Enzymatic synthesis of unlabeled and beta-(32)P-labeled beta-L-2', 3'-dideoxyadenosine-5'-triphosphate as a potent inhibitor of adenylyl cyclases and its use as reversible binding ligand. J Biol Chem 274:34735-41
Shoshani, I; Laux, W H; Perigaud, C et al. (1999) Inhibition of adenylyl cyclase by acyclic nucleoside phosphonate antiviral agents. J Biol Chem 274:34742-4
Doronin, S; Murray, L; Dessauer, C W et al. (1999) Covalent labeling of adenylyl cyclase cytosolic domains with gamma-methylimidazole-2',5'-dideoxy-[gamma-(32)P]3'-ATP and the mechanism for P-site-mediated inhibition. J Biol Chem 274:34745-50
Szczepanik, M B; Desaubry, L; Johnson, R A (1999) Synthesis of nucleoside 3'-thiophosphates in one step procedure. Nucleosides Nucleotides 18:951-3

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