Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK040949-08
Application #
2141535
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Program Officer
Laughlin, Maren R
Project Start
1989-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1998-07-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Chicago
Department
Biochemistry
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Weiss, Michael A; Lawrence, Michael C (2018) A thing of beauty: Structure and function of insulin's ""aromatic triplet"". Diabetes Obes Metab 20 Suppl 2:51-63
Glidden, Michael D; Yang, Yanwu; Smith, Nicholas A et al. (2018) Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding. J Biol Chem 293:69-88
Glidden, Michael D; Aldabbagh, Khadijah; Phillips, Nelson B et al. (2018) An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein. J Biol Chem 293:47-68
Rege, Nischay K; Wickramasinghe, Nalinda P; Tustan, Alisar N et al. (2018) Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic-aromatic interactions. J Biol Chem 293:10895-10910
Rege, Nischay K; Phillips, Nelson F B; Weiss, Michael A (2017) Development of glucose-responsive 'smart' insulin systems. Curr Opin Endocrinol Diabetes Obes 24:267-278
Dhayalan, Balamurugan; Mandal, Kalyaneswar; Rege, Nischay et al. (2017) Scope and Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin. Chemistry 23:1709-1716
Croll, Tristan I; Smith, Brian J; Margetts, Mai B et al. (2016) Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain. Structure 24:469-76
Pandyarajan, Vijay; Phillips, Nelson B; Rege, Nischay et al. (2016) Contribution of TyrB26 to the Function and Stability of Insulin: STRUCTURE-ACTIVITY RELATIONSHIPS AT A CONSERVED HORMONE-RECEPTOR INTERFACE. J Biol Chem 291:12978-90
Dhayalan, Balamurugan; Fitzpatrick, Ann; Mandal, Kalyaneswar et al. (2016) Efficient Total Chemical Synthesis of (13) C=(18) O Isotopomers of Human Insulin for Isotope-Edited FTIR. Chembiochem 17:415-20
El Hage, Krystel; Pandyarajan, Vijay; Phillips, Nelson B et al. (2016) Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY. J Biol Chem 291:27023-27041

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