Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK041513-06
Application #
2141790
Study Section
General Medicine B Study Section (GMB)
Project Start
1990-03-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Force, Thomas; Kuida, Keisuke; Namchuk, Mark et al. (2004) Inhibitors of protein kinase signaling pathways: emerging therapies for cardiovascular disease. Circulation 109:1196-205
Goruppi, Sandro; Bonventre, Joseph V; Kyriakis, John M (2002) Signaling pathways and late-onset gene induction associated with renal mesangial cell hypertrophy. EMBO J 21:5427-36
Porcher, Christophe; Horowitz, Burton; Bayguinov, Orline et al. (2002) Constitutive expression and function of cyclooxygenase-2 in murine gastric muscles. Gastroenterology 122:1442-54
Horiguchi, K; Semple, G S; Sanders, K M et al. (2001) Distribution of pacemaker function through the tunica muscularis of the canine gastric antrum. J Physiol 537:237-50
Makkinje, A; Quinn, D A; Chen, A et al. (2000) Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress. J Biol Chem 275:17838-47
Pombo, C M; Tsujita, T; Kyriakis, J M et al. (1997) Activation of the Ste20-like oxidant stress response kinase-1 during the initial stages of chemical anoxia-induced necrotic cell death. Requirement for dual inputs of oxidant stress and increased cytosolic [Ca2+]. J Biol Chem 272:29372-9
Molnar, A; Theodoras, A M; Zon, L I et al. (1997) Cdc42Hs, but not Rac1, inhibits serum-stimulated cell cycle progression at G1/S through a mechanism requiring p38/RK. J Biol Chem 272:13229-35
Pombo, C M; Bonventre, J V; Molnar, A et al. (1996) Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway. EMBO J 15:4537-46
Morooka, H; Bonventre, J V; Pombo, C M et al. (1995) Ischemia and reperfusion enhance ATF-2 and c-Jun binding to cAMP response elements and to an AP-1 binding site from the c-jun promoter. J Biol Chem 270:30084-92
Pombo, C M; Bonventre, J V; Avruch, J et al. (1994) The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion. J Biol Chem 269:26546-51

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