Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK041875-05S1
Application #
3242816
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1989-08-01
Project End
1994-07-31
Budget Start
1992-10-01
Budget End
1994-07-31
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Wu, J; Zern, M A (2000) Hepatic stellate cells: a target for the treatment of liver fibrosis. J Gastroenterol 35:665-72
Wu, J; Liu, S L; Zhu, J L et al. (2000) Roles of tissue transglutaminase in ethanol-induced inhibition of hepatocyte proliferation and alpha 1-adrenergic signal transduction. J Biol Chem 275:22213-9
Zhu, J; Wu, J; Frizell, E et al. (1999) Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis. Gastroenterology 117:1198-204
Di Campli, C; Wu, J; Zern, M A (1999) Targeting of therapeutics to the liver: liposomes and viral vectors. Alcohol Clin Exp Res 23:950-4
Wu, J; Zern, M A (1999) NF-kappa B, liposomes and pathogenesis of hepatic injury and fibrosis. Front Biosci 4:D520-7
Ozaki, I; Zern, M A; Liu, S et al. (1999) Ribozyme-mediated specific gene replacement of the alpha1-antitrypsin gene in human hepatoma cells. J Hepatol 31:53-60
Zern, M A; Ozaki, I; Duan, L et al. (1999) A novel SV40-based vector successfully transduces and expresses an alpha 1-antitrypsin ribozyme in a human hepatoma-derived cell line. Gene Ther 6:114-20
Wu, J; Liu, P; Zhu, J L et al. (1998) Increased liver uptake of liposomes and improved targeting efficacy by labeling with asialofetuin in rodents. Hepatology 27:772-8
Santos, R M; Norton, P; Degli Esposti, S et al. (1998) TGF-beta isoforms in alcoholic liver disease. J Gastroenterol 33:383-9
Kuncio, G S; Tsyganskaya, M; Zhu, J et al. (1998) TNF-alpha modulates expression of the tissue transglutaminase gene in liver cells. Am J Physiol 274:G240-5

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