Myogenic Control Mechanisms in Internal Anal Sphincter

Bitar, Khalil N.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 3R01DK042876-04S1
• Application #: 2142602
• Study Section: General Medicine A Subcommittee 2 (GMA)
• Project Start: 1991-06-15
• Project End: 1996-05-31
• Budget Start: 1994-06-01
• Budget End: 1996-05-31
• Support Year: 4
• Fiscal Year: 1994

Institution

• Name: University of Michigan Ann Arbor
• Department: Pediatrics
• Type: Schools of Medicine
• DUNS #: 791277940
• City: Ann Arbor
• State: MI
• Country: United States
• Zip Code: 48109

Publications

Zakhem, Elie; Raghavan, Shreya; Bitar, Khalil N (2014) Neo-innervation of a bioengineered intestinal smooth muscle construct around chitosan scaffold. Biomaterials 35:1882-9

Raghavan, Shreya; Bitar, Khalil N (2014) The influence of extracellular matrix composition on the differentiation of neuronal subtypes in tissue engineered innervated intestinal smooth muscle sheets. Biomaterials 35:7429-40

Raghavan, Shreya; Gilmont, Robert R; Bitar, Khalil N (2013) Neuroglial differentiation of adult enteric neuronal progenitor cells as a function of extracellular matrix composition. Biomaterials 34:6649-58

Bitar, Khalil N; Zakhem, Elie (2013) Tissue engineering and regenerative medicine as applied to the gastrointestinal tract. Curr Opin Biotechnol 24:909-15

Zakhem, Elie; Raghavan, Shreya; Gilmont, Robert R et al. (2012) Chitosan-based scaffolds for the support of smooth muscle constructs in intestinal tissue engineering. Biomaterials 33:4810-7

Somara, Sita; Bashllari, Daniela; Gilmont, Robert R et al. (2011) Real-time dynamic movement of caveolin-1 during smooth muscle contraction of human colon and aged rat colon transfected with caveolin-1 cDNA. Am J Physiol Gastrointest Liver Physiol 300:G1022-32

Bitar, K; Greenwood-Van Meerveld, B; Saad, R et al. (2011) Aging and gastrointestinal neuromuscular function: insights from within and outside the gut. Neurogastroenterol Motil 23:490-501

Hashish, Mohamed; Raghavan, Shreya; Somara, Sita et al. (2010) Surgical implantation of a bioengineered internal anal sphincter. J Pediatr Surg 45:52-8

Somara, Sita; Gilmont, Robert R; Varadarajan, Saranyaraajan et al. (2010) Phosphorylated HSP20 modulates the association of thin-filament binding proteins: caldesmon with tropomyosin in colonic smooth muscle. Am J Physiol Gastrointest Liver Physiol 299:G1164-76

Gilmont, Robert R; Somara, Sita; Bitar, Khalil N (2008) VIP induces PKA-mediated rapid and sustained phosphorylation of HSP20. Biochem Biophys Res Commun 375:552-6