Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK043526-06A2
Application #
2143054
Study Section
Metabolism Study Section (MET)
Project Start
1990-06-01
Project End
2000-05-31
Budget Start
1996-06-15
Budget End
1997-05-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Mississippi Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
928824473
City
Jackson
State
MS
Country
United States
Zip Code
39216
Soesanto, Yudi; Luo, Bai; Parker, Glendon et al. (2011) Pleiotropic and age-dependent effects of decreased protein modification by O-linked N-acetylglucosamine on pancreatic ?-cell function and vascularization. J Biol Chem 286:26118-26
Cooksey, Robert C; McClain, Donald A (2011) Increased hexosamine pathway flux and high fat feeding are not additive in inducing insulin resistance: evidence for a shared pathway. Amino Acids 40:841-6
Stapleton, David; Nelson, Chad; Parsawar, Krishna et al. (2010) Analysis of hepatic glycogen-associated proteins. Proteomics 10:2320-9
Shakya, Arvind; Cooksey, Robert; Cox, James E et al. (2009) Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity. Nat Cell Biol 11:320-7
Taylor, Rodrick P; Geisler, Taylor S; Chambers, Jefferson H et al. (2009) Up-regulation of O-GlcNAc transferase with glucose deprivation in HepG2 cells is mediated by decreased hexosamine pathway flux. J Biol Chem 284:3425-32
Luo, Bai; Soesanto, Yudi; McClain, Donald A (2008) Protein modification by O-linked GlcNAc reduces angiogenesis by inhibiting Akt activity in endothelial cells. Arterioscler Thromb Vasc Biol 28:651-7
Soesanto, Yudi A; Luo, Bai; Jones, Deborah et al. (2008) Regulation of Akt signaling by O-GlcNAc in euglycemia. Am J Physiol Endocrinol Metab 295:E974-80
Taylor, Rodrick P; Parker, Glendon J; Hazel, Mark W et al. (2008) Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase. J Biol Chem 283:6050-7
Parker, Glendon; Taylor, Rodrick; Jones, Deborah et al. (2004) Hyperglycemia and inhibition of glycogen synthase in streptozotocin-treated mice: role of O-linked N-acetylglucosamine. J Biol Chem 279:20636-42
Parker, Glendon J; Lund, Kelli C; Taylor, Rodrick P et al. (2003) Insulin resistance of glycogen synthase mediated by o-linked N-acetylglucosamine. J Biol Chem 278:10022-7