Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK043994-06
Application #
2143448
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1991-05-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Stanford University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Fayadat, Laurence; Kopito, Ron R (2003) Recognition of a single transmembrane degron by sequential quality control checkpoints. Mol Biol Cell 14:1268-78
Johnston, Jennifer A; Illing, Michelle E; Kopito, Ron R (2002) Cytoplasmic dynein/dynactin mediates the assembly of aggresomes. Cell Motil Cytoskeleton 53:26-38
Gelman, Marina S; Kannegaard, Elisa S; Kopito, Ron R (2002) A principal role for the proteasome in endoplasmic reticulum-associated degradation of misfolded intracellular cystic fibrosis transmembrane conductance regulator. J Biol Chem 277:11709-14
Illing, Michelle E; Rajan, Rahul S; Bence, Neil F et al. (2002) A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system. J Biol Chem 277:34150-60
Kopito, R R (1999) Biosynthesis and degradation of CFTR. Physiol Rev 79:S167-73
Yu, H; Kopito, R R (1999) The role of multiubiquitination in dislocation and degradation of the alpha subunit of the T cell antigen receptor. J Biol Chem 274:36852-8
Sato, S; Ward, C L; Kopito, R R (1998) Cotranslational ubiquitination of cystic fibrosis transmembrane conductance regulator in vitro. J Biol Chem 273:7189-92
Johnston, J A; Ward, C L; Kopito, R R (1998) Aggresomes: a cellular response to misfolded proteins. J Cell Biol 143:1883-98
Yu, H; Kaung, G; Kobayashi, S et al. (1997) Cytosolic degradation of T-cell receptor alpha chains by the proteasome. J Biol Chem 272:20800-4
Sato, S; Ward, C L; Krouse, M E et al. (1996) Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation. J Biol Chem 271:635-8

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