Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK044128-02S1
Application #
3245626
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1992-01-15
Project End
1996-12-31
Budget Start
1993-06-01
Budget End
1993-12-31
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Wassner, Ari J; Jugo, Rebecca H; Dorfman, David M et al. (2017) Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy. Thyroid 27:732-737
Luongo, Cristina; Martin, Cecilia; Vella, Kristen et al. (2015) The selective loss of the type 2 iodothyronine deiodinase in mouse thyrotrophs increases basal TSH but blunts the thyrotropin response to hypothyroidism. Endocrinology 156:745-54
Wittmann, Gábor; Harney, John W; Singru, Praful S et al. (2014) Inflammation-inducible type 2 deiodinase expression in the leptomeninges, choroid plexus, and at brain blood vessels in male rodents. Endocrinology 155:2009-19
Maynard, Michelle A; Marino-Enriquez, Adrian; Fletcher, Jonathan A et al. (2014) Thyroid hormone inactivation in gastrointestinal stromal tumors. N Engl J Med 370:1327-34
Salvatore, Domenico; Simonides, Warner S; Dentice, Monica et al. (2014) Thyroid hormones and skeletal muscle--new insights and potential implications. Nat Rev Endocrinol 10:206-14
Dentice, Monica; Ambrosio, Raffaele; Damiano, Valentina et al. (2014) Intracellular inactivation of thyroid hormone is a survival mechanism for muscle stem cell proliferation and lineage progression. Cell Metab 20:1038-48
Zavacki, Ann Marie; Larsen, P Reed (2013) RTH?, a newly recognized phenotype of the resistance to thyroid hormone (RTH) syndrome in patients with THRA gene mutations. J Clin Endocrinol Metab 98:2684-6
Hong, Eun-Gyoung; Kim, Brian W; Jung, Dae Young et al. (2013) Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice. Endocrinology 154:3937-46
Dentice, Monica; Marsili, Alessandro; Zavacki, Annmarie et al. (2013) The deiodinases and the control of intracellular thyroid hormone signaling during cellular differentiation. Biochim Biophys Acta 1830:3937-45
Larsen, P Reed; Zavacki, Ann Marie (2012) The role of the iodothyronine deiodinases in the physiology and pathophysiology of thyroid hormone action. Eur Thyroid J 1:232-242

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