Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK044442-03
Application #
2143795
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1994-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1998-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Northeast Ohio Medical University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Rootstown
State
OH
Country
United States
Zip Code
44272
Donepudi, Ajay C; Ferrell, Jessica M; Boehme, Shannon et al. (2018) Deficiency of cholesterol 7?-hydroxylase in bile acid synthesis exacerbates alcohol-induced liver injury in mice. Hepatol Commun 2:99-112
Pathak, Preeti; Xie, Cen; Nichols, Robert G et al. (2018) Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism. Hepatology 68:1574-1588
Chiang, John Y L; Ferrell, Jessica M (2018) Bile Acid Metabolism in Liver Pathobiology. Gene Expr 18:71-87
Chiang, John Y L (2017) Linking Sex Differences in Non-Alcoholic Fatty Liver Disease to Bile Acid Signaling, Gut Microbiota, and High Fat Diet. Am J Pathol 187:1658-1659
Chiang, John Y L (2017) Linking long noncoding RNA to control bile acid signaling and cholestatic liver fibrosis. Hepatology 66:1032-1035
Chiang, John Y L; Pathak, Preeti; Liu, Hailiang et al. (2017) Intestinal Farnesoid X Receptor and Takeda G Protein Couple Receptor 5 Signaling in Metabolic Regulation. Dig Dis 35:241-245
Chiang, John Y L (2017) Bile acid metabolism and signaling in liver disease and therapy. Liver Res 1:3-9
Pathak, Preeti; Liu, Hailiang; Boehme, Shannon et al. (2017) Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism. J Biol Chem 292:11055-11069
Donepudi, Ajay C; Boehme, Shannon; Li, Feng et al. (2017) G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice. Hepatology 65:813-827
Chiang, John Y L (2017) Targeting bile acids and lipotoxicity for NASH treatment. Hepatol Commun 1:1002-1004

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