Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK044632-12
Application #
6634990
Study Section
General Medicine A Subcommittee 2 (GMA)
Program Officer
Hamilton, Frank A
Project Start
1993-05-01
Project End
2005-04-30
Budget Start
2003-05-01
Budget End
2004-04-30
Support Year
12
Fiscal Year
2003
Total Cost
$263,200
Indirect Cost

  Institution

Name
University of California Irvine
Department
Pathology
Type
Schools of Medicine
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Cobo, Eduardo R; Holani, Ravi; Moreau, France et al. (2018) Entamoeba histolytica Alters ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency. Infect Immun :
Tai, Kenneth P; Kamdar, Karishma; Yamaki, Jason et al. (2015) Microbicidal effects of ?- and ?-defensins against antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Innate Immun 21:17-29
Mastroianni, Jennifer R; Lu, Wuyuan; Selsted, Michael E et al. (2014) Differential Susceptibility of Bacteria to Mouse Paneth Cell ?-Defensins under Anaerobic Conditions. Antibiotics (Basel) 3:493-508
Tai, Kenneth P; Le, Valerie V; Selsted, Michael E et al. (2014) Hydrophobic determinants of ?-defensin bactericidal activity. Infect Immun 82:2195-202
Patil, Amar A; Ouellette, Andre J; Lu, Wuyuan et al. (2013) Rattusin, an intestinal ?-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities. Antimicrob Agents Chemother 57:1823-31
Andersson, Håkan S; Figueredo, Sharel M; Haugaard-Kedström, Linda M et al. (2012) The ?-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance. Amino Acids 43:1471-83
Schaal, Justin B; Tran, Dat; Tran, Patti et al. (2012) Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis. PLoS One 7:e51337
Schmidt, Nathan W; Tai, Kenneth P; Kamdar, Karishma et al. (2012) Arginine in ?-defensins: differential effects on bactericidal activity correspond to geometry of membrane curvature generation and peptide-lipid phase behavior. J Biol Chem 287:21866-72
Tongaonkar, Prasad; Golji, Amir E; Tran, Patti et al. (2012) High fidelity processing and activation of the human ?-defensin HNP1 precursor by neutrophil elastase and proteinase 3. PLoS One 7:e32469
Mastroianni, Jennifer R; Costales, Jessica K; Zaksheske, Jennifer et al. (2012) Alternative luminal activation mechanisms for paneth cell ?-defensins. J Biol Chem 287:11205-12

Showing the most recent 10 out of 27 publications