Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK046906-03
Application #
2146192
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1994-05-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Paulsen, Friedrich P; Woon, Chee-Wai; Varoga, Deike et al. (2008) Intestinal trefoil factor/TFF3 promotes re-epithelialization of corneal wounds. J Biol Chem 283:13418-27
Kalabis, Jiri; Rosenberg, Ian; Podolsky, Daniel K (2006) Vangl1 protein acts as a downstream effector of intestinal trefoil factor (ITF)/TFF3 signaling and regulates wound healing of intestinal epithelium. J Biol Chem 281:6434-41
Beck, P L; Wong, J F; Li, Y et al. (2004) Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor. Gastroenterology 126:796-808
Fernandez-Estivariz, Concepcion; Gu, Li H; Gu, Liang et al. (2003) Trefoil peptide expression and goblet cell number in rat intestine: effects of KGF and fasting-refeeding. Am J Physiol Regul Integr Comp Physiol 284:R564-73
Iwakiri, D; Podolsky, D K (2001) A silencer inhibitor confers specific expression of intestinal trefoil factor in gobletlike cell lines. Am J Physiol Gastrointest Liver Physiol 280:G1114-23
Andoh, A; Kinoshita, K; Rosenberg, I et al. (2001) Intestinal trefoil factor induces decay-accelerating factor expression and enhances the protective activities against complement activation in intestinal epithelial cells. J Immunol 167:3887-93
Iwakiri, D; Podolsky, D K (2001) Keratinocyte growth factor promotes goblet cell differentiation through regulation of goblet cell silencer inhibitor. Gastroenterology 120:1372-80
Taupin, D R; Kinoshita, K; Podolsky, D K (2000) Intestinal trefoil factor confers colonic epithelial resistance to apoptosis. Proc Natl Acad Sci U S A 97:799-804
Podolsky, D K (2000) Review article: healing after inflammatory injury--coordination of a regulatory peptide network. Aliment Pharmacol Ther 14 Suppl 1:87-93
Kinoshita, K; Taupin, D R; Itoh, H et al. (2000) Distinct pathways of cell migration and antiapoptotic response to epithelial injury: structure-function analysis of human intestinal trefoil factor. Mol Cell Biol 20:4680-90

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