Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK046950-01A2
Application #
2146259
Study Section
General Medicine B Study Section (GMB)
Project Start
1996-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Weill Medical College of Cornell University
Department
Physiology
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Nanazashvili, Mikheil; Sánchez-Rodríguez, Jorge E; Fosque, Ben et al. (2018) LRET Determination of Molecular Distances during pH Gating of the Mammalian Inward Rectifier Kir1.1b. Biophys J 114:88-97
Sackin, Henry; Nanazashvili, Mikheil; Makino, Shin-ichi (2015) Direct injection of cell-free Kir1.1 protein into Xenopus oocytes replicates single-channel currents derived from Kir1.1 mRNA. Channels (Austin) 9:196-9
Frindt, Gustavo; Li, Hui; Sackin, Henry et al. (2013) Inhibition of ROMK channels by low extracellular K+ and oxidative stress. Am J Physiol Renal Physiol 305:F208-15
Yang, Lei; Edvinsson, Johan; Sackin, Henry et al. (2012) Ion selectivity and current saturation in inward-rectifier K+ channels. J Gen Physiol 139:145-57
Sackin, Henry; Nanazashvili, Mikheil; Li, Hui et al. (2012) Residues at the outer mouth of Kir1.1 determine K-dependent gating. Biophys J 102:2742-50
Wang, Hao-Ran; Wu, Meng; Yu, Haibo et al. (2011) Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem Biol 6:845-56
Sackin, Henry; Nanazashvili, Mikheil; Li, Hui et al. (2011) Modulation of Kir1.1 inactivation by extracellular Ca and Mg. Biophys J 100:1207-15
Sackin, Henry; Nanazashvili, Mikheil; Li, Hui et al. (2010) A conserved arginine near the filter of Kir1.1 controls Rb/K selectivity. Channels (Austin) 4:203-14
Sackin, Henry; Nanazashvili, Mikheil; Li, Hui et al. (2009) An intersubunit salt bridge near the selectivity filter stabilizes the active state of Kir1.1. Biophys J 97:1058-66
Sackin, Henry; Nanazashvili, Mikheil; Li, Hui et al. (2007) External K activation of Kir1.1 depends on the pH gate. Biophys J 93:L14-6

Showing the most recent 10 out of 24 publications