Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK047418-01A1S1
Application #
2146999
Study Section
General Medicine B Study Section (GMB)
Project Start
1994-08-01
Project End
1995-07-31
Budget Start
1994-09-01
Budget End
1995-07-31
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Boston University
Department
Miscellaneous
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Kaya, Taner; Swamy, Narasimha; Persons, Kelly S et al. (2009) Covalent labeling of nuclear vitamin D receptor with affinity labeling reagents containing a cross-linking probe at three different positions of the parent ligand: structural and biochemical implications. Bioorg Chem 37:57-63
Kisker, Oliver; Onizuka, Shinya; Becker, Christian M et al. (2003) Vitamin D binding protein-macrophage activating factor (DBP-maf) inhibits angiogenesis and tumor growth in mice. Neoplasia 5:32-40
Addo, James K; Swamy, Narasimha; Ray, Rahul (2002) The C(19) position of 25-hydroxyvitamin D(3) faces outward in the vitamin D sterol-binding pocket of vitamin D-binding protein. Bioorg Med Chem Lett 12:279-81
Mohr, S C; Swamy, N; Xu, W et al. (2001) Why do we need a three-dimensional architecture of the ligand-binding domain of the nuclear 1alpha,25-dihydroxyvitamin D(3) receptor? Steroids 66:189-201
Swamy, N; Ghosh, S; Schneider, G B et al. (2001) Baculovirus-expressed vitamin D-binding protein-macrophage activating factor (DBP-maf) activates osteoclasts and binding of 25-hydroxyvitamin D(3) does not influence this activity. J Cell Biochem 81:535-46
Swamy, N; Addo, J K; Ray, R (2000) Development of an affinity-driven cross-linker: isolation of a vitamin D receptor associated factor. Bioorg Med Chem Lett 10:361-4
Nemere, I; Ray, R; McManus, W (2000) Immunochemical studies on the putative plasmalemmal receptor for 1, 25(OH)(2)D(3). I. Chick intestine. Am J Physiol Endocrinol Metab 278:E1104-14
Swamy, N; Xu, W; Paz, N et al. (2000) Molecular modeling, affinity labeling, and site-directed mutagenesis define the key points of interaction between the ligand-binding domain of the vitamin D nuclear receptor and 1 alpha,25-dihydroxyvitamin D3. Biochemistry 39:12162-71
Swamy, N; Addo, J; Vskokovic, M R et al. (2000) Probing the vitamin D sterol-binding pocket of human vitamin D-binding protein with bromoacetate affinity labeling reagents containing the affinity probe at C-3, C-6, C-11, and C-19 positions of parent vitamin D sterols. Arch Biochem Biophys 373:471-8
Chen, M L; Ray, S; Swamy, N et al. (1999) Mechanistic studies to evaluate the enhanced antiproliferation of human keratinocytes by 1alpha,25-dihydroxyvitamin D(3)-3-bromoacetate, a covalent modifier of vitamin D receptor, compared to 1alpha,25-dihydroxyvitamin D(3). Arch Biochem Biophys 370:34-44

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