Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK047874-02
Application #
2147780
Study Section
General Medicine B Study Section (GMB)
Project Start
1995-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Edinger, Robert S; Coronnello, Claudia; Bodnar, Andrew J et al. (2014) Aldosterone regulates microRNAs in the cortical collecting duct to alter sodium transport. J Am Soc Nephrol 25:2445-57
Weixel, Kelly M; Marciszyn, Allison; Alzamora, Rodrigo et al. (2013) Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells. PLoS One 8:e78019
Argyropoulos, Christos; Wang, Kai; McClarty, Sara et al. (2013) Urinary microRNA profiling in the nephropathy of type 1 diabetes. PLoS One 8:e54662
Butterworth, Michael B; Edinger, Robert S; Silvis, Mark R et al. (2012) Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC). Am J Physiol Renal Physiol 302:F581-90
Edinger, Robert S; Bertrand, Carol A; Rondandino, Christine et al. (2012) The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation. PLoS One 7:e46593
Hallows, Kenneth R; Wang, Huamin; Edinger, Robert S et al. (2009) Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem 284:5774-83
Edinger, Robert S; Lebowitz, Jonathan; Li, Hui et al. (2009) Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. J Biol Chem 284:150-7
Weixel, Kelly M; Edinger, Robert S; Kester, Lauren et al. (2007) Phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (ENaC) in cultured collecting duct cells. J Biol Chem 282:36534-42
Butterworth, Michael B; Edinger, Robert S; Ovaa, Huib et al. (2007) The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel. J Biol Chem 282:37885-93
Hill, Warren G; Butterworth, Michael B; Wang, Huamin et al. (2007) The epithelial sodium channel (ENaC) traffics to apical membrane in lipid rafts in mouse cortical collecting duct cells. J Biol Chem 282:37402-11

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