This revised application seeks to study androgen-regulated genes in the rat prostate.
Aim 1 is to test the hypothesis that calreticulin down-regulation facilitates Ca++ ionophore-induced prostatic cell death.
Aim 2 is to continue and expand identification of androgen-responsive genes in the prostate.
Aim 3 is to characterize the spatial and temporal androgenic regulation of potentially important response genes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK051193-01A1
Application #
2017193
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1996-12-18
Project End
2000-11-30
Budget Start
1996-12-18
Budget End
1997-11-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Urology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
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Saporita, Anthony J; Ai, Junkui; Wang, Zhou (2007) The Hsp90 inhibitor, 17-AAG, prevents the ligand-independent nuclear localization of androgen receptor in refractory prostate cancer cells. Prostate 67:509-20
Oram, Shane W; Ai, Junkui; Pagani, Gina M et al. (2007) Expression and function of the human androgen-responsive gene ADI1 in prostate cancer. Neoplasia 9:643-51
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Xiao, Wuhan; Jiang, Feng; Wang, Zhou (2006) ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation. Prostate 66:1-12
Jiang, Feng; Wang, Zhou (2004) Identification and characterization of PLZF as a prostatic androgen-responsive gene. Prostate 59:426-35
Oram, Shane; Jiang, Feng; Cai, Xiaoyan et al. (2004) Identification and characterization of an androgen-responsive gene encoding an aci-reductone dioxygenase-like protein in the rat prostate. Endocrinology 145:1933-42
Abasolo, Ibane; Wang, Zhou; Montuenga, Luis M et al. (2004) Adrenomedullin inhibits prostate cancer cell proliferation through a cAMP-independent autocrine mechanism. Biochem Biophys Res Commun 322:878-86

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