Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK054755-04
Application #
6517523
Study Section
General Medicine A Subcommittee 2 (GMA)
Program Officer
May, Michael K
Project Start
2000-05-01
Project End
2005-04-30
Budget Start
2002-05-01
Budget End
2003-04-30
Support Year
4
Fiscal Year
2002
Total Cost
$250,250
Indirect Cost
Name
University of Tennessee Health Science Center
Department
Physiology
Type
Schools of Medicine
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163
George, Sudeep P; Chen, Hongfeng; Conrad, Jacinta C et al. (2013) Regulation of directional cell migration by membrane-induced actin bundling. J Cell Sci 126:312-26
Wang, Y; George, S P; Srinivasan, K et al. (2012) Actin reorganization as the molecular basis for the regulation of apoptosis in gastrointestinal epithelial cells. Cell Death Differ 19:1514-24
Khurana, Seema; George, Sudeep P (2011) The role of actin bundling proteins in the assembly of filopodia in epithelial cells. Cell Adh Migr 5:409-20
Tomar, Alok; George, Sudeep P; Mathew, Sijo et al. (2009) Differential effects of lysophosphatidic acid and phosphatidylinositol 4,5-bisphosphate on actin dynamics by direct association with the actin-binding protein villin. J Biol Chem 284:35278-82
Khurana, Seema; Tomar, Alok; George, Sudeep P et al. (2008) Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia. Exp Cell Res 314:530-42
Khurana, Seema; George, Sudeep P (2008) Regulation of cell structure and function by actin-binding proteins: villin's perspective. FEBS Lett 582:2128-39
Wang, Yaohong; Srinivasan, Kamalakkannan; Siddiqui, Mohammad Rizwan et al. (2008) A novel role for villin in intestinal epithelial cell survival and homeostasis. J Biol Chem 283:9454-64
Mathew, Sijo; George, Sudeep P; Wang, Yaohong et al. (2008) Potential molecular mechanism for c-Src kinase-mediated regulation of intestinal cell migration. J Biol Chem 283:22709-22
George, Sudeep P; Wang, Yaohong; Mathew, Sijo et al. (2007) Dimerization and actin-bundling properties of villin and its role in the assembly of epithelial cell brush borders. J Biol Chem 282:26528-41
Wang, Yaohong; Tomar, Alok; George, Sudeep P et al. (2007) Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration. Am J Physiol Cell Physiol 292:C1775-86

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