Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES003765-10
Application #
2153427
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1985-03-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Kansas
Department
Pharmacology
Type
Schools of Medicine
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160

  Publications

LeCluyse, E L; Ahlgren-Beckendorf, J A; Carroll, K et al. (2000) Regulation of glutathione S-transferase enzymes in primary cultures of rat hepatocytes maintained under various matrix configurations. Toxicol In Vitro 14:101-15
Liu, J; Sendelbach, L E; Parkinson, A et al. (2000) Endotoxin pretreatment protects against the hepatotoxicity of acetaminophen and carbon tetrachloride: role of cytochrome P450 suppression. Toxicology 147:167-76
LeCluyse, E; Madan, A; Hamilton, G et al. (2000) Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. J Biochem Mol Toxicol 14:177-88
LeCluyse, E; Bullock, P; Madan, A et al. (1999) Influence of extracellular matrix overlay and medium formulation on the induction of cytochrome P-450 2B enzymes in primary cultures of rat hepatocytes. Drug Metab Dispos 27:909-15
Granvil, C P; Madan, A; Sharkawi, M et al. (1999) Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes. Drug Metab Dispos 27:533-41
Madan, A; DeHaan, R; Mudra, D et al. (1999) Effect of cryopreservation on cytochrome P-450 enzyme induction in cultured rat hepatocytes. Drug Metab Dispos 27:327-35
Dwyer-Nield, L D; Thompson, J A; Peljak, G et al. (1998) Selective induction of apoptosis in mouse and human lung epithelial cell lines by the tert-butyl hydroxylated metabolite of butylated hydroxytoluene: a proposed role in tumor promotion. Toxicology 130:115-27
Madan, A; Parkinson, A; Faiman, M D (1998) Identification of the human P-450 enzymes responsible for the sulfoxidation and thiono-oxidation of diethyldithiocarbamate methyl ester: role of P-450 enzymes in disulfiram bioactivation. Alcohol Clin Exp Res 22:1212-9
Draper, A J; Madan, A; Smith, K et al. (1998) Development of a non-high pressure liquid chromatography assay to determine testosterone hydroxylase (CYP3A) activity in human liver microsomes. Drug Metab Dispos 26:299-304
Draper, A J; Madan, A; Latham, J et al. (1998) Development of a non-high pressure liquid chromatography assay to determine [14C]chlorzoxazone 6-hydroxylase (CYP2E1) activity in human liver microsomes. Drug Metab Dispos 26:305-12

Showing the most recent 10 out of 56 publications