Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES003771-11
Application #
2153430
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1993-08-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington State University
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
041485301
City
Pullman
State
WA
Country
United States
Zip Code
99164
Zangar, R C; Kimzey, A L; Okita, J R et al. (2002) Cytochrome P450 3A conjugation to ubiquitin in a process distinct from classical ubiquitination pathway. Mol Pharmacol 61:892-904
Okita, R T; Okita, J R (2001) Cytochrome P450 4A fatty acid omega hydroxylases. Curr Drug Metab 2:265-81
Zangar, R C; Okita, J R; Kim, H et al. (1999) Effect of calcium channel antagonists nifedipine and nicardipine on rat cytochrome P-450 2B and 3A forms. J Pharmacol Exp Ther 290:1436-41
Okita, J R; Johnson, S B; Castle, P J et al. (1997) Improved separation and immunodetection of rat cytochrome P450 4A forms in liver and kidney. Drug Metab Dispos 25:1008-12
Okita, R T; Okita, J R (1996) Prostaglandin-metabolizing enzymes during pregnancy: characterization of NAD(+)-dependent prostaglandin dehydrogenase, carbonyl reductase, and cytochrome P450-dependent prostaglandin omega-hydroxylase. Crit Rev Biochem Mol Biol 31:101-26
Austin, E W; Okita, J R; Okita, R T et al. (1995) Modification of lipoperoxidative effects of dichloroacetate and trichloroacetate is associated with peroxisome proliferation. Toxicology 97:59-69
Castle, P J; Merdink, J L; Okita, J R et al. (1995) Human liver lauric acid hydroxylase activities. Drug Metab Dispos 23:1037-43
Okita, J R; Castle, P J; Okita, R T (1993) Characterization of cytochromes P450 in liver and kidney of rats treated with di-(2-ethylhexyl)phthalate. J Biochem Toxicol 8:135-44
Okita, R T; Okita, J R (1992) Effects of diethyl phthalate and other plasticizers on laurate hydroxylation in rat liver microsomes. Pharm Res 9:1648-53
Okita, R T; Clark, J E; Okita, J R et al. (1991) Omega- and (omega-1)-hydroxylation of eicosanoids and fatty acids by high-performance liquid chromatography. Methods Enzymol 206:432-41

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