Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES004041-10
Application #
2153525
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
1986-04-01
Project End
1997-01-31
Budget Start
1995-04-01
Budget End
1997-01-31
Support Year
10
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Washington
Department
Pharmacology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Trofimova-Griffin, Marina E; Juchau, Mont R (2002) Developmental expression of cytochrome CYP26B1 (P450RAI-2) in human cephalic tissues. Brain Res Dev Brain Res 136:175-8
Person, R E; Chen, H; Fantel, A G et al. (2000) Enzymic catalysis of the accumulation of acetaldehyde from ethanol in human prenatal cephalic tissues: evaluation of the relative contributions of CYP2E1, alcohol dehydrogenase, and catalase/peroxidases. Alcohol Clin Exp Res 24:1433-42
Trofimova-Griffin, M E; Brzezinski, M R; Juchau, M R (2000) Patterns of CYP26 expression in human prenatal cephalic and hepatic tissues indicate an important role during early brain development. Brain Res Dev Brain Res 120:16-Jul
Khalighi, M; Brzezinski, M R; Chen, H et al. (1999) Inhibition of human prenatal biosynthesis of all-trans-retinoic acid by ethanol, ethanol metabolites, and products of lipid peroxidation reactions: a possible role for CYP2E1. Biochem Pharmacol 57:811-21
Brzezinski, M R; Boutelet-Bochan, H; Person, R E et al. (1999) Catalytic activity and quantitation of cytochrome P-450 2E1 in prenatal human brain. J Pharmacol Exp Ther 289:1648-53
Chen, H; Brzezinski, M R; Fantel, A G et al. (1999) Catalysis of drug oxidation during embryogenesis in human hepatic tissues using imipramine as a model substrate. Drug Metab Dispos 27:1306-8
Chen, H; Juchau, M R (1998) Biotransformation of 13-cis- and 9-cis-retinoic acid to all-trans-retinoic acid in rat conceptal homogenates. Evidence for catalysis by a conceptal isomerase. Drug Metab Dispos 26:222-8
Chen, H; Juchau, M R (1998) Inhibition of embryonic retinoic acid synthesis by aldehydes of lipid peroxidation and prevention of inhibition by reduced glutathione and glutathione S-transferases. Free Radic Biol Med 24:408-17
Trofimova-Griffin, M E; Juchau, M R (1998) Expression of cytochrome P450RAI (CYP26) in human fetal hepatic and cephalic tissues. Biochem Biophys Res Commun 252:487-91
Chen, H; Juchau, M R (1998) Recombinant human glutathione S-transferases catalyse enzymic isomerization of 13-cis-retinoic acid to all-trans-retinoic acid in vitro. Biochem J 336 ( Pt 1):223-6

Showing the most recent 10 out of 54 publications