Toxicological Significance of Alkylbenzene Metabolism

Backes, Wayne L.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Research Project (R01)
• Project #: 2R01ES004344-06A4
• Application #: 2153661
• Study Section: Toxicology Subcommittee 2 (TOX)
• Project Start: 1988-01-15
• Project End: 2001-04-30
• Budget Start: 1996-05-01
• Budget End: 1997-04-30
• Support Year: 6
• Fiscal Year: 1996

Institution

• Name: Louisiana State University Hsc New Orleans
• Department: Pharmacology
• Type: Schools of Medicine
• DUNS #: 782627814
• City: New Orleans
• State: LA
• Country: United States
• Zip Code: 70112

Publications

Connick, J Patrick; Reed, James R; Backes, Wayne L (2018) Characterization of Interactions Among CYP1A2, CYP2B4, and NADPH-cytochrome P450 Reductase: Identification of Specific Protein Complexes. Drug Metab Dispos 46:197-203

Reed, James R; Backes, Wayne L (2017) Physical Studies of P450-P450 Interactions: Predicting Quaternary Structures of P450 Complexes in Membranes from Their X-ray Crystal Structures. Front Pharmacol 8:28

Brignac-Huber, Lauren M; Park, Ji Won; Reed, James R et al. (2016) Cytochrome P450 Organization and Function Are Modulated by Endoplasmic Reticulum Phospholipid Heterogeneity. Drug Metab Dispos 44:1859-1866

Reed, James R; Backes, Wayne L (2016) The functional effects of physical interactions involving cytochromes P450: putative mechanisms of action and the extent of these effects in biological membranes. Drug Metab Rev 48:453-69

Scott, Emily E; Wolf, C Roland; Otyepka, Michal et al. (2016) The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function. Drug Metab Dispos 44:576-90

Park, Ji Won; Reed, James R; Backes, Wayne L (2015) The Localization of Cytochrome P450s CYP1A1 and CYP1A2 into Different Lipid Microdomains Is Governed by Their N-terminal and Internal Protein Regions. J Biol Chem 290:29449-60

Reed, James R; dela Cruz, Albert Leo N; Lomnicki, Slawo M et al. (2015) Environmentally persistent free radical-containing particulate matter competitively inhibits metabolism by cytochrome P450 1A2. Toxicol Appl Pharmacol 289:223-30

Reed, James R; dela Cruz, Albert Leo N; Lomnicki, Slawo M et al. (2015) Inhibition of cytochrome P450 2B4 by environmentally persistent free radical-containing particulate matter. Biochem Pharmacol 95:126-32

Johnson, Eric F; Connick, J Patrick; Reed, James R et al. (2014) Correlating structure and function of drug-metabolizing enzymes: progress and ongoing challenges. Drug Metab Dispos 42:9-22

Reed, James R; Cawley, George F; Ardoin, Taylor G et al. (2014) Environmentally persistent free radicals inhibit cytochrome P450 activity in rat liver microsomes. Toxicol Appl Pharmacol 277:200-9