Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
3R01ES004348-10S1
Application #
2153666
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1984-08-01
Project End
1997-08-31
Budget Start
1995-09-01
Budget End
1996-08-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Horn, T L; O'Brien, T D; Schook, L B et al. (2000) Acute hepatotoxicant exposure induces TNFR-mediated hepatic injury and cytokine/apoptotic gene expression. Toxicol Sci 54:262-73
Horn, T L; Bhattacharjee, A; Schook, L B et al. (2000) Altered hepatic mRNA expression of apoptotic genes during dimethylnitrosamine exposure. Toxicol Sci 57:240-9
Bhattacharjee, A; Lappi, V R; Rutherford, M S et al. (1998) Molecular dissection of dimethylnitrosamine (DMN)-induced hepatotoxicity by mRNA differential display. Toxicol Appl Pharmacol 150:186-95
Bhattacharjee, A; Rutherford, M S; Abrahamsen, M S et al. (1997) Refinements in re-amplification and cloning of DDRT-PCR products. Biotechniques 22:1048-51
Yang, S D; Schook, L B; Rutherford, M S (1995) Differential expression of novel genes by bone marrow-derived macrophage populations. Mol Immunol 32:733-42
Myers, M J; Ghildyal, N; Schook, L B (1995) Endotoxin and interferon-gamma differentially regulate the transcriptional levels of proto-oncogenes and cytokine genes during the differentiation of colony-stimulating factor type-1-derived macrophages. Immunology 85:318-24
Lockwood, J F; Rutherford, M S; Myers, M J et al. (1994) Induction of hepatic acute-phase protein transcripts: differential effects of acute and subchronic dimethylnitrosamine exposure in vivo. Toxicol Appl Pharmacol 125:288-95
Schook, L B; Albrecht, H; Gallay, P et al. (1994) Cytokine regulation of TNF-alpha mRNA and protein production by unprimed macrophages from C57Bl/6 and NZW mice. J Leukoc Biol 56:514-20
Rutherford, M S; Witsell, A; Schook, L B (1993) Mechanisms generating functionally heterogeneous macrophages: chaos revisited. J Leukoc Biol 53:602-18
Rutherford, M S; Schook, L B (1992) Macrophage function in response to PGE2, L-arginine deprivation, and activation by colony-stimulating factors is dependent on hematopoietic stimulus. J Leukoc Biol 52:228-35

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