Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
3R01ES004804-06S1
Application #
2406445
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1989-05-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
6
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225
Leyva, Francisco J; Pershouse, Mark A; Holian, Andrij (2010) Modified low density lipoproteins binding requires a lysine cluster region in the murine macrophage scavenger receptor class A type II. Mol Biol Rep 37:2847-52
Pfau, Jean C; Sentissi, Jami J; Li, Sheng'ai et al. (2008) Asbestos-induced autoimmunity in C57BL/6 mice. J Immunotoxicol 5:129-37
Brown, Jared M; Swindle, Emily J; Kushnir-Sukhov, Nataliya M et al. (2007) Silica-directed mast cell activation is enhanced by scavenger receptors. Am J Respir Cell Mol Biol 36:43-52
Hamilton Jr, Raymond F; Thakur, Sheetal A; Mayfair, Jolene K et al. (2006) MARCO mediates silica uptake and toxicity in alveolar macrophages from C57BL/6 mice. J Biol Chem 281:34218-26
Pfau, Jean C; Sentissi, Jami J; Weller, Greg et al. (2005) Assessment of autoimmune responses associated with asbestos exposure in Libby, Montana, USA. Environ Health Perspect 113:25-30
Migliaccio, Christopher T; Hamilton Jr, Raymond F; Holian, Andrij (2005) Increase in a distinct pulmonary macrophage subset possessing an antigen-presenting cell phenotype and in vitro APC activity following silica exposure. Toxicol Appl Pharmacol 205:168-76
Beamer, Celine A; Holian, Andrij (2005) Scavenger receptor class A type I/II (CD204) null mice fail to develop fibrosis following silica exposure. Am J Physiol Lung Cell Mol Physiol 289:L186-95
Hamilton Jr, Raymond F; Holian, Andrij; Morandi, Maria T (2004) A comparison of asbestos and urban particulate matter in the in vitro modification of human alveolar macrophage antigen-presenting cell function. Exp Lung Res 30:147-62
Pfau, Jean C; Brown, Jared M; Holian, Andrij (2004) Silica-exposed mice generate autoantibodies to apoptotic cells. Toxicology 195:167-76
Hamilton Jr, Raymond F; Parsley, Ed; Holian, Andrij (2004) Alveolar macrophages from systemic sclerosis patients: evidence for IL-4-mediated phenotype changes. Am J Physiol Lung Cell Mol Physiol 286:L1202-9

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