Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
2R01ES005865-04
Application #
2154734
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1993-05-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of South Alabama
Department
Biology
Type
Schools of Medicine
DUNS #
City
Mobile
State
AL
Country
United States
Zip Code
36688
Rachek, Lyudmila I; Yuzefovych, Larysa V; Ledoux, Susan P et al. (2009) Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes. Toxicol Appl Pharmacol 240:348-54
Druzhyna, Nadiya M; Wilson, Glenn L; LeDoux, Susan P (2008) Mitochondrial DNA repair in aging and disease. Mech Ageing Dev 129:383-90
Ho, Renee; Rachek, Lyudmila I; Xu, Yi et al. (2007) Yeast apurinic/apyrimidinic endonuclease Apn1 protects mammalian neuronal cell line from oxidative stress. J Neurochem 102:13-24
Harrison, Jason F; Rinne, Mikael L; Kelley, Mark R et al. (2007) Altering DNA base excision repair: use of nuclear and mitochondrial-targeted N-methylpurine DNA glycosylase to sensitize astroglia to chemotherapeutic agents. Glia 55:1416-25
LeDoux, S P; Druzhyna, N M; Hollensworth, S B et al. (2007) Mitochondrial DNA repair: a critical player in the response of cells of the CNS to genotoxic insults. Neuroscience 145:1249-59
Ray, L S; Chatterjee, S; Berger, N A et al. (1996) Catalytic activity of poly(ADP-ribose) polymerase is necessary for repair of N-methylpurines in nontranscribed, but not in transcribed, nuclear DNA sequences. Mutat Res 363:105-14