Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES006109-04
Application #
2154938
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1992-12-10
Project End
1996-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Pathology
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Ma, Jihong; DeFrances, Marie C; Zou, Chunbin et al. (2009) Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancer. J Clin Invest 119:478-91
Zhao, Yongge; Difrancesca, Daniell; Wang, Xue et al. (2007) Promotion of Fas-mediated apoptosis in Type II cells by high doses of hepatocyte growth factor bypasses the mitochondrial requirement. J Cell Physiol 213:556-63
Jiang, J G; Johnson, C; Zarnegar, R (2001) Peroxisome proliferator-activated receptor gamma-mediated transcriptional up-regulation of the hepatocyte growth factor gene promoter via a novel composite cis-acting element. J Biol Chem 276:25049-56
Jiang, J G; Gao, B; Zarnegar, R (2000) The concerted regulatory functions of the transcription factors nuclear factor-1 and upstream stimulatory factor on a composite element in the promoter of the hepatocyte growth factor gene. Oncogene 19:2786-90
Jiang, J G; DeFrances, M C; Machen, J et al. (2000) The repressive function of AP2 transcription factor on the hepatocyte growth factor gene promoter. Biochem Biophys Res Commun 272:882-6
Bell, A; Chen, Q; DeFrances, M C et al. (1999) The five amino acid-deleted isoform of hepatocyte growth factor promotes carcinogenesis in transgenic mice. Oncogene 18:887-95
Bell, A W; Jiang, J G; Chen, Q et al. (1998) The upstream regulatory regions of the hepatocyte growth factor gene promoter are essential for its expression in transgenic mice. J Biol Chem 273:6900-8
Jiang, J G; Bell, A; Liu, Y et al. (1997) Transcriptional regulation of the hepatocyte growth factor gene by the nuclear receptors chicken ovalbumin upstream promoter transcription factor and estrogen receptor. J Biol Chem 272:3928-34
Jiang, J G; Chen, Q; Bell, A et al. (1997) Transcriptional regulation of the hepatocyte growth factor (HGF) gene by the Sp family of transcription factors. Oncogene 14:3039-49
Jiang, J G; Zarnegar, R (1997) A novel transcriptional regulatory region within the core promoter of the hepatocyte growth factor gene is responsible for its inducibility by cytokines via the C/EBP family of transcription factors. Mol Cell Biol 17:5758-70

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