Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES006189-04
Application #
2155056
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1992-12-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Pittman-Polletta, Benjamin; Hu, Kun; Kocsis, Bernat (2018) Subunit-specific NMDAR antagonism dissociates schizophrenia subtype-relevant oscillopathies associated with frontal hypofunction and hippocampal hyperfunction. Sci Rep 8:11588
Zhang, Xiao-Lei; McGlothan, Jennifer L; Miry, Omid et al. (2018) From the Cover: 7,8-Dihydroxyflavone Rescues Lead-Induced Impairment of Vesicular Release: A Novel Therapeutic Approach for Lead Intoxicated Children. Toxicol Sci 161:186-195
Wagner, Peter J; Park, Hae-Ryung; Wang, Zhaoxi et al. (2017) In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Up-regulated Genes and Cognitive Scores in Children. Environ Health Perspect 125:721-729
Austin, Rachel Narehood; Freeman, Jennifer L; Guilarte, Tomás R (2016) Neurochemistry of lead and manganese. Metallomics 8:561-2
Guariglia, Sara Rose; Stansfield, Kirstie H; McGlothan, Jennifer et al. (2016) Chronic early life lead (Pb2+) exposure alters presynaptic vesicle pools in hippocampal synapses. BMC Pharmacol Toxicol 17:56
Stansfield, K H; Ruby, K N; Soares, B D et al. (2015) Early-life lead exposure recapitulates the selective loss of parvalbumin-positive GABAergic interneurons and subcortical dopamine system hyperactivity present in schizophrenia. Transl Psychiatry 5:e522
Zhang, Xiao-Lei; Guariglia, Sara R; McGlothan, Jennifer L et al. (2015) Presynaptic mechanisms of lead neurotoxicity: effects on vesicular release, vesicle clustering and mitochondria number. PLoS One 10:e0127461
Abazyan, Bagrat; Dziedzic, Jenifer; Hua, Kegang et al. (2014) Chronic exposure of mutant DISC1 mice to lead produces sex-dependent abnormalities consistent with schizophrenia and related mental disorders: a gene-environment interaction study. Schizophr Bull 40:575-84
Neal, April P; Guilarte, Tomas R (2013) Mechanisms of lead and manganese neurotoxicity. Toxicol Res (Camb) 2:99-114
Kang, N; Peng, H; Yu, Y et al. (2013) Astrocytes release D-serine by a large vesicle. Neuroscience 240:243-57

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