Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
2R01EY002568-19
Application #
2158457
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1978-08-01
Project End
2001-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
A.T. Still University of Health Sciences
Department
Biochemistry
Type
Schools of Osteopathy
DUNS #
City
Kirksville
State
MO
Country
United States
Zip Code
63501
Cenedella, Richard J (2009) Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes. Lipids 44:477-87
Cenedella, Richard J; Sexton, Patricia S; Brako, Lawrence et al. (2007) Status of caveolin-1 in various membrane domains of the bovine lens. Exp Eye Res 85:473-81
Cenedella, Richard J; Neely, Amanda R; Sexton, Patricia (2006) Multiple forms of 22 kDa caveolin-1 alpha present in bovine lens cells could reflect variable palmitoylation. Exp Eye Res 82:229-35
Cenedella, Richard J; Sexton, Patricia S; Krishnan, Kathiresan et al. (2005) Comparison of effects of U18666A and enantiomeric U18666A on sterol synthesis and induction of apoptosis. Lipids 40:635-40
Cenedella, Richard J; Neely, Amanda R; Sexton, Patricia (2005) Concentration and distribution of ubiquinone (coenzyme Q), the endogenous lipid antioxidant, in the rat lens: effect of treatment with simvastatin. Mol Vis 11:594-602
Cenedella, Richard J; Jacob, Robert; Borchman, Douglas et al. (2004) Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor. J Lipid Res 45:1232-41
Sexton, Patricia S; Neely, Amanda R; Cenedella, Richard J (2004) Distribution of caveolin-1 in bovine lens and redistribution in cultured bovine lens epithelial cells upon confluence. Exp Eye Res 78:75-82
Cenedella, Richard J; Kuszak, Jerome R; Al-Ghoul, Kristin J et al. (2003) Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb: Thom rats. J Lipid Res 44:198-211
Jacob, R F; Cenedella, R J; Mason, R P (2001) Evidence for distinct cholesterol domains in fiber cell membranes from cataractous human lenses. J Biol Chem 276:13573-8
Cenedella, R J (2001) Specific labeling of lens aldehyde dehydrogenase class 1 from (3)H-cholesterol or its derivatives. Ophthalmic Res 33:210-6

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