This proposal stems from discoveries made during the last project period, the goal of which was to understand the high-gain state of the primary visual cortex (V1) that was turned on during locomotion in mice. During the current project period we discovered, among other things, that the high-gain state of the visual cortex is mediated by the action of local vasoactive intestinal peptide positive (VIP) interneurons. This circuit gates rapid plasticity in visual cortical responses that is stimulus-specific, cell-specific, and persistent at least for weeks in adult mice. The major hypothesis to be tested in the current proposal is that this form of stimulus- specific plasticity in primary visual cortex is a substrate of visual perceptual learning. The present proposal seeks first to elucidate the properties of this form of adult plasticity that are relevant to perceptual learning, specifically its specificity for stimulus configuration and retinal locus. Second, it seeks to understand the cellular signaling mechanisms responsible for this plasticity and to determine whether its persistence is due of rewiring of excitatory and inhibitory connectionsa in the visual cortex. Finally, it seeks to measure the specificity of visual perceptual learning in mice behaviorally and to determine whether the VIP-cell circuit that enhances responses and neural plasticity is a substrate of visual perceptual learning. The findings from this study may guide approaches to therapy for amblyopia and dyslexia.
This proposal seeks to understand the signaling mechanisms and behavioral consequences of an important form of plasticity in the visual cortex of adult mice that is gated by the activity of a particular type of interneuron that puts the cortex into a high-gain state.
| Dyballa, Luciano; Hoseini, Mahmood S; Dadarlat, Maria C et al. (2018) Flow stimuli reveal ecologically appropriate responses in mouse visual cortex. Proc Natl Acad Sci U S A 115:11304-11309 |
| Stryker, Michael P; Löwel, Siegrid (2018) Amblyopia: New molecular/pharmacological and environmental approaches. Vis Neurosci 35:E018 |
| Kaneko, Megumi; Stryker, Michael P (2017) Homeostatic plasticity mechanisms in mouse V1. Philos Trans R Soc Lond B Biol Sci 372: |
| Fox, Kevin; Stryker, Michael (2017) Integrating Hebbian and homeostatic plasticity: introduction. Philos Trans R Soc Lond B Biol Sci 372: |
| Keck, Tara; Toyoizumi, Taro; Chen, Lu et al. (2017) Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions. Philos Trans R Soc Lond B Biol Sci 372: |
| Dadarlat, Maria C; Stryker, Michael P (2017) Locomotion Enhances Neural Encoding of Visual Stimuli in Mouse V1. J Neurosci 37:3764-3775 |
| Kaneko, Megumi; Fu, Yu; Stryker, Michael P (2017) Locomotion Induces Stimulus-Specific Response Enhancement in Adult Visual Cortex. J Neurosci 37:3532-3543 |
| Larimer, Phillip; Spatazza, Julien; Espinosa, Juan Sebastian et al. (2016) Caudal Ganglionic Eminence Precursor Transplants Disperse and Integrate as Lineage-Specific Interneurons but Do Not Induce Cortical Plasticity. Cell Rep 16:1391-1404 |
| Owens, Melinda T; Feldheim, David A; Stryker, Michael P et al. (2015) Stochastic Interaction between Neural Activity and Molecular Cues in the Formation of Topographic Maps. Neuron 87:1261-1273 |
| Fu, Yu; Kaneko, Megumi; Tang, Yunshuo et al. (2015) A cortical disinhibitory circuit for enhancing adult plasticity. Elife 4:e05558 |
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