Abstract

In this application the principal investigator proposes to examine synaptic inputs, membrane properties and the distribution NMDA receptors on cells in the cat superior colliculus that contain calbindin (CB), parvalbumin (PV), nitric oxide synthetase (NOS). The principal investigator believes that these cell groups offer an opportunity to examine the relationships between chemical content, afferent input and physiology in a well- characterized system.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY002973-17
Application #
2701341
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1992-01-01
Project End
2000-04-30
Budget Start
1998-05-01
Budget End
2000-04-30
Support Year
17
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Louisiana State University Hsc New Orleans
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112

  Publications

Mize, R Ranney; Graham, Sean K; Cork, R John (2002) Expression of the L-type calcium channel in the developing mouse visual system by use of immunocytochemistry. Brain Res Dev Brain Res 136:185-95
Lo, Fu-Sun; Mize, R Ranney (2002) Properties of LTD and LTP of retinocollicular synaptic transmission in the developing rat superior colliculus. Eur J Neurosci 15:1421-32
Scheiner, C A; Kratz, K E; Guido, W et al. (2001) Prenatal and postnatal expression of nitric oxide in the developing kitten superior colliculus revealed with NADPH diaphorase histochemistry. Vis Neurosci 18:43-54
Wu, H H; Cork, R J; Mize, R R (2000) Normal development of the ipsilateral retinocollicular pathway and its disruption in double endothelial and neuronal nitric oxide synthase gene knockout mice. J Comp Neurol 426:651-65
Cork, R J; Calhoun, T; Perrone, M et al. (2000) Postnatal development of nitric oxide synthase expression in the mouse superior colliculus. J Comp Neurol 427:581-92
Lo, F S; Mize, R R (2000) Synaptic regulation of L-type Ca(2+) channel activity and long-term depression during refinement of the retinocollicular pathway in developing rodent superior colliculus. J Neurosci 20:RC58
Mize, R R; Butler, G D (2000) The NMDAR1 subunit of the N-methyl-D-aspartate receptor is localized at postsynaptic sites opposite both retinal and cortical terminals in the cat superior colliculus. Vis Neurosci 17:41-53
Wu, H H; Cork, R J; Huang, P L et al. (2000) Refinement of the ipsilateral retinocollicular projection is disrupted in double endothelial and neuronal nitric oxide synthase gene knockout mice. Brain Res Dev Brain Res 120:105-11
Mize, R R; Lo, F (2000) Nitric oxide, impulse activity, and neurotrophins in visual system development(1). Brain Res 886:15-32
Scheiner, C A; Cork, R J; Mize, R R (1999) Failure to disrupt development of cholinergic fiber patches in the superior colliculus in nitric oxide synthase deficient mice. Brain Res Dev Brain Res 118:217-20

Showing the most recent 10 out of 49 publications