Abstract

The cornea is a principal refractive element in the eye; corneal transparency and corneal shape determine its optical qualities. Corneal epithelial edema, stromal edema and corneal shape anomalies can independently or collectively degrade visual performance inthe form of increased internal ligh scatter andoptical aberrations due to irregular astigmatism. The central theme of this research proposalis the refinement and application of a mathematical model that integrates the thermodynamic description of corneal epithelial, stromal and endothelial transport properties into a model of corneal hydration control. This is combined with methods to classify shape anomalies and means to assess the optical quality of the corneal surface through the analysis of corneal topography.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY003311-20
Application #
2888106
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1979-07-01
Project End
2002-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
20
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Louisiana State University Hsc New Orleans
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112

  Publications

Smolek, Michael K; Klyce, Stephen D (2007) Absolute color scale for improved diagnostics with wavefront error mapping. Ophthalmology 114:2022-30
Tabernero, Juan; Klyce, Stephen D; Sarver, Edwin J et al. (2007) Functional optical zone of the cornea. Invest Ophthalmol Vis Sci 48:1053-60
Klyce, Stephen D; Karon, Michael D; Smolek, Michael K (2005) Screening patients with the corneal navigator. J Refract Surg 21:S617-22
Smolek, Michael K; Klyce, Stephen D (2005) Goodness-of-prediction of Zernike polynomial fitting to corneal surfaces. J Cataract Refract Surg 31:2350-5
Klyce, Stephen D; Karon, Michael D; Smolek, Michael K (2004) Advantages and disadvantages of the Zernike expansion for representing wave aberration of the normal and aberrated eye. J Refract Surg 20:S537-41
Courville, C B; Smolek, M K; Klyce, S D (2004) Contribution of the ocular surface to visual optics. Exp Eye Res 78:417-25
Klyce, Stephen D (2004) Night vision after LASIK: the pupil proclaims innocence. Ophthalmology 111:1-2
Goto, Tomoko; Zheng, Xiaodong; Klyce, Stephen D et al. (2004) Evaluation of the tear film stability after laser in situ keratomileusis using the tear film stability analysis system. Am J Ophthalmol 137:116-20
Ruberti, Jeffrey W; Klyce, Stephen D (2003) NaCl osmotic perturbation can modulate hydration control in rabbit cornea. Exp Eye Res 76:349-59
Ambrosio Jr, Renato; Klyce, Stephen D; Wilson, Steven E (2003) Corneal topographic and pachymetric screening of keratorefractive patients. J Refract Surg 19:24-9

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