Abstract

The proposed studies will investigate two adaptive mechanisms of vergence eye movements which underlie the development and maintenance of binocular eye alignment. The adaptive mechanisms are changes in tonic innervation to vergence in response to prism and adaptive gain control of interactions between accommodation and convergence. Postnatal development of these two adaptive functions will be examined in normal preschool children over the age range when accommodative esotropia usually appears. Visual and extraretinal stimuli for tonic vergence adaptation will be investigated in normals and strabismic patients with anomalous retinal correspondence who exhibit anomalous fusional movements in response to corrective prism. Comparisons will also be made between the amplitude and duration of adaptive gain changes of accommodative vergence and vergence accommodation in normals and patients with binocular disorders. The results will provide information about adaptive control of vergence, factors underlying the postnatal onset of accomodative esotropia and factors underlying binocular motor disorders such as strabismus which can lead to secondary sensory disorders such as amblyopia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY003532-06
Application #
3257889
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1981-09-30
Project End
1989-11-30
Budget Start
1986-12-01
Budget End
1987-11-30
Support Year
6
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of California Berkeley
Department
Type
Schools of Optometry/Opht Tech
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704

  Publications

Keay, Lisa; Edwards, Katie; Stapleton, Fiona (2009) Signs, symptoms, and comorbidities in contact lens-related microbial keratitis. Optom Vis Sci 86:803-9
Schor, Clifton M (2009) Charles F. Prentice award lecture 2008: surgical correction of presbyopia with intraocular lenses designed to accommodate. Optom Vis Sci 86:E1028-41
Schor, Clifton M (2009) Neuromuscular plasticity and rehabilitation of the ocular near response. Optom Vis Sci 86:E788-802
Schreiber, Kai M; Hillis, James M; Filippini, Heather R et al. (2008) The surface of the empirical horopter. J Vis 8:7.1-20
Nguyen, Dorothy; Vedamurthy, Indu; Schor, Clifton (2008) Cross-coupling between accommodation and convergence is optimized for a broad range of directions and distances of gaze. Vision Res 48:893-903
Hernandez, Teresa D; Levitan, Carmel A; Banks, Martin S et al. (2008) How does saccade adaptation affect visual perception? J Vis 8:3.1-16
Schreiber, Kai M; Schor, Clifton M (2007) A virtual ophthalmotrope illustrating oculomotor coordinate systems and retinal projection geometry. J Vis 7:4.1-14
Bharadwaj, Shrikant R; Hoenig, M Pia; Sivaramakrishnan, Viswanathan C et al. (2007) Variation of binocular-vertical fusion amplitude with convergence. Invest Ophthalmol Vis Sci 48:1592-600
Weiler, Julia A; Maxwell, James S; Schor, Clifton M (2007) Illusory contrast-induced shifts in binocular visual direction bias saccadic eye movements toward the perceived target position. J Vis 7:3.1-18
Schor, Clifton M; Bharadwaj, Shrikant R; Burns, Christopher D (2007) Dynamic performance of accommodating intraocular lenses in a negative feedback control system: a simulation-based study. Comput Biol Med 37:1020-35

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