Abstract

The primary goal of this project is to elucidate the molecular mechanisms of photoreceptor excitation. We propose to accomplish this objective by using a combined electrophysiological and pharmacological approach. We also propose to develop biochemical assays that will yield data that can be correlated with our physiological-pharmacological findings.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY003793-08
Application #
3258240
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1987-09-01
Project End
1989-08-31
Budget Start
1988-09-01
Budget End
1989-08-31
Support Year
8
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Connecticut
Department
Type
School of Medicine & Dentistry
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030

  Publications

Fein, A; Cavar, S (2000) Divergent mechanisms for phototransduction of invertebrate microvillar photoreceptors. Vis Neurosci 17:911-7
Vallet, A M; Fein, A (1997) A role for hydrolysis of inositol 1,4,5-trisphosphate in terminating the response to inositol 1,4,5-trisphosphate and to a flash of light in Limulus ventral photoreceptors. Brain Res 768:91-101
Poitry, S; Tsacopoulos, M; Fein, A et al. (1996) Kinetics of oxygen consumption and light-induced changes of nucleotides in solitary rod photoreceptors. J Gen Physiol 108:75-87
Feng, J J; Carson, J H; Morgan, F et al. (1994) Three-dimensional organization of endoplasmic reticulum in the ventral photoreceptors of Limulus. J Comp Neurol 341:172-83
Terasaki, M; Slater, N T; Fein, A et al. (1994) Continuous network of endoplasmic reticulum in cerebellar Purkinje neurons. Proc Natl Acad Sci U S A 91:7510-4
Jones, G J; Fein, A; MacNichol Jr, E F et al. (1993) Visual pigment bleaching in isolated salamander retinal cones. Microspectrophotometry and light adaptation. J Gen Physiol 102:483-502
Feng, J J; Frank, T M; Fein, A (1991) Excitation of Limulus photoreceptors by hydrolysis-resistant analogs of cGMP and cAMP. Brain Res 552:291-4
Frank, T M; Fein, A (1991) The role of the inositol phosphate cascade in visual excitation of invertebrate microvillar photoreceptors. J Gen Physiol 97:697-723
Cornwall, M C; Fein, A; MacNichol Jr, E F (1990) Cellular mechanisms that underlie bleaching and background adaptation. J Gen Physiol 96:345-72
Naegele, J R; Katz, L C (1990) Cell surface molecules containing N-acetylgalactosamine are associated with basket cells and neurogliaform cells in cat visual cortex. J Neurosci 10:540-57

Showing the most recent 10 out of 20 publications