The goal is to measure the dimensions of the human photoreceptor mosaic, and to describe the impact of the mosaic on spatial vision in different parts of the visual field. A psychophysical technique will be developed to measure the packing arrangement, spacing, and size of cones across the central retina. This noninvasive technique exploits the appearance of moire patterns formed between fine interference fringes and the cone mosaic to deduce the structure of the mosaic in the living eye. The results of the moire technique will be validated with results from an improved anatomical technique, that will allow measurements of the dimension of the human cone mosaic with minimum histological artifact. The quantitative description of the human cone mosaic derived from the psychophysical and anatomical results will be used to construct a model of the first stages of spatial vision. In addition to the photoreceptor mosaic, the model will incorporate the optical quality of the eye and neural spatial filtering, and will predict the spatial performance of the visual system at each retinal eccentricity. These predictions will be compared with acuity and contrast sensitivity measurements made with interference fringes, to provide a clearer understanding of the limitaitons imposed ;by the first stages of the visual system on pattern vision.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY004367-08
Application #
3258748
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1982-07-01
Project End
1990-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
8
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Rochester
Department
Type
Schools of Arts and Sciences
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
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Granger, Charles E; Yang, Qiang; Song, Hongxin et al. (2018) Human Retinal Pigment Epithelium: In Vivo Cell Morphometry, Multispectral Autofluorescence, and Relationship to Cone Mosaic. Invest Ophthalmol Vis Sci 59:5705-5716
de la Barca, Juan Manuel Chao; Huang, Nuan-Ting; Jiao, Haihan et al. (2017) Retinal metabolic events in preconditioning light stress as revealed by wide-spectrum targeted metabolomics. Metabolomics 13:22
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