Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY004396-12
Application #
2159055
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1983-09-01
Project End
1997-03-31
Budget Start
1995-04-01
Budget End
1997-03-31
Support Year
12
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Biochemistry
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
Sahu, Mukesh; Sharma, Rajendra; Yadav, Sushma et al. (2014) Lens specific RLIP76 transgenic mice show a phenotype similar to microphthalmia. Exp Eye Res 118:125-34
Chaudhary, Pankaj; Sharma, Rajendra; Sahu, Mukesh et al. (2013) 4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia telangiectasia mutated and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) signaling pathway. J Biol Chem 288:20532-46
Vatsyayan, Rit; Lelsani, Poorna Chandra Rao; Chaudhary, Pankaj et al. (2012) The expression and function of vascular endothelial growth factor in retinal pigment epithelial (RPE) cells is regulated by 4-hydroxynonenal (HNE) and glutathione S-transferaseA4-4. Biochem Biophys Res Commun 417:346-51
Sharma, Rajendra; Sharma, Abha; Chaudhary, Pankaj et al. (2012) Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane. Free Radic Biol Med 52:2177-85
Vatsyayan, Rit; Chaudhary, Pankaj; Sharma, Abha et al. (2011) Role of 4-hydroxynonenal in epidermal growth factor receptor-mediated signaling in retinal pigment epithelial cells. Exp Eye Res 92:147-54
Chaudhary, Pankaj; Sharma, Rajendra; Sharma, Abha et al. (2010) Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling. Biochemistry 49:6263-75
Sharma, Rajendra; Sharma, Abha; Chaudhary, Pankaj et al. (2010) Role of lipid peroxidation in cellular responses to D,L-sulforaphane, a promising cancer chemopreventive agent. Biochemistry 49:3191-202
Sharma, Rajendra; Sharma, Abha; Dwivedi, Seema et al. (2008) 4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas. Biochemistry 47:143-56