Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY004873-12
Application #
2159186
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1984-07-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Aroca-Aguilar, Jose-Daniel; Sanchez-Sanchez, Francisco; Martinez-Redondo, Francisco et al. (2008) Heterozygous expression of myocilin glaucoma mutants increases secretion of the mutant forms and reduces extracellular processed myocilin. Mol Vis 14:2097-108
Lopez-Martinez, Francisco; Lopez-Garrido, Maria-Pilar; Sanchez-Sanchez, Francisco et al. (2007) Role of MYOC and OPTN sequence variations in Spanish patients with primary open-angle glaucoma. Mol Vis 13:862-72
Coca-Prados, Miguel; Escribano, Julio (2007) New perspectives in aqueous humor secretion and in glaucoma: the ciliary body as a multifunctional neuroendocrine gland. Prog Retin Eye Res 26:239-62
Sanchez-Sanchez, Francisco; Martinez-Redondo, Francisco; Aroca-Aguilar, J Daniel et al. (2007) Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease. J Biol Chem 282:27810-24
Ghosh, Sikha; Choritz, Lars; Geibel, John et al. (2006) Somatostatin modulates PI3K-Akt, eNOS and NHE activity in the ciliary epithelium. Mol Cell Endocrinol 253:63-75
Li, Yanxia; Aroca-Aguilar, J Daniel; Ghosh, Sikha et al. (2006) Interaction of myocilin with the C-terminal region of hevin. Biochem Biophys Res Commun 339:797-804
Lopez-Garrido, Maria-Pilar; Sanchez-Sanchez, Francisco; Lopez-Martinez, Francisco et al. (2006) Heterozygous CYP1B1 gene mutations in Spanish patients with primary open-angle glaucoma. Mol Vis 12:748-55
Salvador-Silva, Mercedes; Ghosh, Sikha; Bertazolli-Filho, Rubens et al. (2005) Retinoid processing proteins in the ocular ciliary epithelium. Mol Vis 11:356-65
Aroca-Aguilar, J Daniel; Sanchez-Sanchez, Francisco; Ghosh, Sikha et al. (2005) Myocilin mutations causing glaucoma inhibit the intracellular endoproteolytic cleavage of myocilin between amino acids Arg226 and Ile227. J Biol Chem 280:21043-51
Fidzinski, Pawel; Salvador-Silva, Mercedes; Choritz, Lars et al. (2004) Inhibition of NHE-1 Na+/H+ exchanger by natriuretic peptides in ocular nonpigmented ciliary epithelium. Am J Physiol Cell Physiol 287:C655-63

Showing the most recent 10 out of 60 publications