Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY004900-14
Application #
2159201
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1986-04-01
Project End
1997-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
North Carolina State University Raleigh
Department
Anatomy/Cell Biology
Type
Schools of Veterinary Medicine
DUNS #
City
Raleigh
State
NC
Country
United States
Zip Code
27695
Goralska, Malgorzata; Fleisher, Lloyd N; McGahan, M Christine (2017) Vitreous Humor Changes Expression of Iron-Handling Proteins in Lens Epithelial Cells. Invest Ophthalmol Vis Sci 58:1187-1195
Harned, Jill; Nagar, Steven; McGahan, M Christine (2014) Hypoxia controls iron metabolism and glutamate secretion in retinal pigmented epithelial cells. Biochim Biophys Acta 1840:3138-44
Goralska, Ma?gorzata; Fleisher, Lloyd N; McGahan, M Christine (2014) Hypoxia induced changes in expression of proteins involved in iron uptake and storage in cultured lens epithelial cells. Exp Eye Res 125:135-41
Lall, Marilyn M; Harned, Jill; McGahan, M Christine (2013) Hydrogen peroxide and extracellular signal-related kinase 1/2 pathway regulate ferritin levels in retinal pigmented and lens epithelial cells. Mol Vis 19:2106-12
Goralska, Ma?gorzata; Nagar, Steven; Fleisher, Lloyd N et al. (2013) Source-dependent intracellular distribution of iron in lens epithelial cells cultured under normoxic and hypoxic conditions. Invest Ophthalmol Vis Sci 54:7666-73
Harned, J; Ferrell, J; Nagar, S et al. (2012) Ceruloplasmin alters intracellular iron regulated proteins and pathways: ferritin, transferrin receptor, glutamate and hypoxia-inducible factor-1ýý. Exp Eye Res 97:90-7
Harned, Jill; Ferrell, Jenny; Lall, Marilyn M et al. (2010) Altered ferritin subunit composition: change in iron metabolism in lens epithelial cells and downstream effects on glutathione levels and VEGF secretion. Invest Ophthalmol Vis Sci 51:4437-46
Goralska, Malgorzata; Nagar, Steven; Colitz, Carmen M H et al. (2009) Changes in ferritin H- and L-chains in canine lenses with age-related nuclear cataract. Invest Ophthalmol Vis Sci 50:305-10
Goralska, M; Ferrell, J; Harned, J et al. (2009) Iron metabolism in the eye: a review. Exp Eye Res 88:204-15
Goralska, M; Nagar, S; Fleisher, L N et al. (2009) Distribution of ferritin chains in canine lenses with and without age-related nuclear cataracts. Mol Vis 15:2404-10