Neurons in visual cortex exhibit a remarkable selectivity for certain features of the visual stimulus--a selectivity that must reflect an underlying specificity in the organization of their synaptic connections. Much of the anatomical specificity in cortical circuitry depends on the precise arrangement of intracortical axon arbors. For example, intrinsic axon arbors are responsible for interconnecting selected subsets of neurons that reside in different cortical layers; they are also responsible for selectively linking columns of neurons that share similar response properties. The proposed experiments focus on another dimension of intrinsic axonal connections which, while less conspicuous, may be no less important: the arrangement of axonal connections with respect to the map of visual space. The goal is to determine whether specificity in the topographic arrangement of intracortical axons, like laminar and modular specificity, plays a role in shaping the visual responses of cortical neurons. Previous studies have shown that individual cortical neurons often give rise to axon arbors that are elongated across the cortical surface, extending farther and giving rise to more terminals along one axis of the map of visual space than along the others. A combination of anatomical and physiological methods will be used to: (1) examine the relaxation between this anisotropy in connections and the preference of cortical neurons for oriented edges and (2) examine how this anisotropy might contribute to the response properties of cortical neurons. These experiments should provide new insights into the rules that govern the organization of local circuits in visual cortex--information that is crucial for understanding the neural basis of visual perception.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
3R01EY006821-16S1
Application #
6806906
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Oberdorfer, Michael
Project Start
1987-09-01
Project End
2005-03-31
Budget Start
2003-04-01
Budget End
2004-03-31
Support Year
16
Fiscal Year
2003
Total Cost
$150,000
Indirect Cost
Name
Duke University
Department
Biology
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Lee, Kuo-Sheng; Huang, Xiaoying; Fitzpatrick, David (2016) Topology of ON and OFF inputs in visual cortex enables an invariant columnar architecture. Nature 533:90-4
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Meng, Yicong; Tanaka, Shigeru; Poon, Chi-Sang (2012) Comment on ""Universality in the evolution of orientation columns in the visual cortex"". Science 336:413; author reply 413
Johnson, Elizabeth N; Van Hooser, Stephen D; Fitzpatrick, David (2010) The representation of S-cone signals in primary visual cortex. J Neurosci 30:10337-50
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MacEvoy, Sean P; Tucker, Thomas R; Fitzpatrick, David (2009) A precise form of divisive suppression supports population coding in the primary visual cortex. Nat Neurosci 12:637-45
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