Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY006990-10
Application #
2161148
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1987-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Taylor, J L; Unverrich, D; O'Brien, W J et al. (2000) Interferon coordinately inhibits the disruption of PML-positive ND10 and immediate-early gene expression by herpes simplex virus. J Interferon Cytokine Res 20:805-15
O'Brien, W J; Narasimhan, J; Guy, J et al. (1998) The effects of interferon-alpha and acyclovir on herpes simplex virus type-1 ribonucleotide reductase. Antiviral Res 38:107-16
Taylor, J L; Grossberg, S E (1998) The effects of interferon-alpha on the production and action of other cytokines. Semin Oncol 25:23-9
Taylor, J L; Witt, P L; Irizarry, A et al. (1995) 2',5'-oligoadenylate synthetase in interferon-alpha- and acyclovir-treated herpes simplex virus-infected cells. J Interferon Cytokine Res 15:27-30
Taylor, J L; Tom, P; Guy, J et al. (1994) Regulation of herpes simplex virus thymidine kinase in cells treated with a synergistic antiviral combination of alpha interferon and acyclovir. Antimicrob Agents Chemother 38:853-6
Taylor, J L; Punda-Polic, V; O'Brien, W J (1991) Combined anti-herpes virus activity of nucleoside analogs and interferon. Curr Eye Res 10 Suppl:205-11
Hendricks, R L; Weber, P C; Taylor, J L et al. (1991) Endogenously produced interferon alpha protects mice from herpes simplex virus type 1 corneal disease. J Gen Virol 72 ( Pt 7):1601-10
O'Brien, W J; Coe, E C; Taylor, J L (1990) Nucleoside metabolism in herpes simplex virus-infected cells following treatment with interferon and acyclovir, a possible mechanism of synergistic antiviral activity. Antimicrob Agents Chemother 34:1178-82
Taylor, J L; Grossberg, S E (1990) Recent progress in interferon research: molecular mechanisms of regulation, action, and virus circumvention. Virus Res 15:1-25
Taylor, J L; Casey, M S; O'Brien, W J (1989) Synergistic antiherpes virus activity of acyclovir and interferon in human corneal stromal cells. Invest Ophthalmol Vis Sci 30:365-70

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