Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
3R01EY007546-06S1
Application #
2161544
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1991-08-01
Project End
1995-03-31
Budget Start
1992-03-01
Budget End
1995-03-31
Support Year
6
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Wayne State University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Yamazaki, Akio; Hayashi, Fumio; Matsuura, Isao et al. (2011) Binding of cGMP to the transducin-activated cGMP phosphodiesterase, PDE6, initiates a large conformational change involved in its deactivation. FEBS J 278:1854-72
Yamazaki, Akio; Tatsumi, Masahiro; Bondarenko, Vladimir A et al. (2010) Mechanism for the regulation of mammalian cGMP phosphodiesterase6. 2: isolation and characterization of the transducin-activated form. Mol Cell Biochem 339:235-51
Yamazaki, Akio; Bondarenko, Vladimir A; Matsuura, Isao et al. (2010) Mechanism for the regulation of mammalian cGMP phosphodiesterase6. 1: identification of its inhibitory subunit complexes and their roles. Mol Cell Biochem 339:215-33
Yamazaki, Akio; Moskvin, Oleg; Yamazaki, Russell K (2002) Phosphorylation by cyclin-dependent protein kinase 5 of the regulatory subunit (Pgamma) of retinal cgmp phosphodiesterase (PDE6): its implications in phototransduction. Adv Exp Med Biol 514:131-53
Matsuura, I; Bondarenko, V A; Maeda, T et al. (2000) Phosphorylation by cyclin-dependent protein kinase 5 of the regulatory subunit of retinal cGMP phosphodiesterase. I. Identification of the kinase and its role in the turnoff of phosphodiesterase in vitro. J Biol Chem 275:32950-7
Hayashi, F; Matsuura, I; Kachi, S et al. (2000) Phosphorylation by cyclin-dependent protein kinase 5 of the regulatory subunit of retinal cGMP phosphodiesterase. II. Its role in the turnoff of phosphodiesterase in vivo. J Biol Chem 275:32958-65
Kachi, S; Yamazaki, M; Tanaka, Y et al. (2000) Structural change of bovine retinal cGMP phosphodiesterase by release of its gamma subunit: direct imaging by improved low angle rotary shadowing. J Electron Microsc (Tokyo) 49:699-708
Kachi, S; Nishizawa, Y; Olshevskaya, E et al. (1999) Detailed localization of photoreceptor guanylate cyclase activating protein-1 and -2 in mammalian retinas using light and electron microscopy. Exp Eye Res 68:465-73
Bondarenko, V A; Yamazaki, M; Hayashi, F et al. (1999) Suppression of GTP/T alpha-dependent activation of cGMP phosphodiesterase by ADP-ribosylation by its gamma subunit in amphibian rod photoreceptor membranes. Biochemistry 38:7755-63
Yu, H; Olshevskaya, E; Duda, T et al. (1999) Activation of retinal guanylyl cyclase-1 by Ca2+-binding proteins involves its dimerization. J Biol Chem 274:15547-55

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