The proposed research will investigate the effects of aging, age-related maculopathy and macular degeneration (ARM/AMD) and atherosclerotic disease on cones, rods and the retinal pigment epithelium (RPE) cells and beneath the photoreceptors. The strategy is to compare structure to function employing a variety of methods, including confocal laser imaging of the fundus with red and infrared light to identify and describe structural changes from normal, aged and diseased eyes, using reflectometry to measure photoreceptor optics, densitometry to determine pigment density, and psychophysical measures of retinal function. The cardiovascular study will measure photoreceptor function before and after rehabilitation to determine what function is improved and reflected in blood studies. Plans also are included to investigate the effects of cardiovascular disease and glaucoma on photoreceptor/RPE layers of patients with ARM/AMD. These studies should provide tests for risk factors and noninvasive early detection, as well as possibly providing a better classification scheme and more accurate prognostic tests for patients with ARM/AMD.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY007624-11
Application #
6384589
Study Section
Visual Sciences C Study Section (VISC)
Program Officer
Dudley, Peter A
Project Start
1987-09-01
Project End
2002-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
11
Fiscal Year
2001
Total Cost
$256,294
Indirect Cost
Name
Schepens Eye Research Institute
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02114
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