Abstract

The electroretinogram, ERG, is currently a valuable noninvasive technique available for diagnosing and following the course of retinal diseases. It has recently been shown that the initial portion of the human ERG can provide a quantitative measure of human rod receptor activity (Hood & Birch, 1990). These findings suggest that the ERG can be employed to answer fundamental questions about the functioning of both normal and abnormal human rod photoreceptors. Understanding rod receptor involvement in different diseases and in the normal process of light adaptation are among the specific aims of the proposed research. Our successful application of a quantitative model of the rod from the animal physiological literature encourages us to extent this work along two lines. First, we propose to measure cone a-waves and to compare them to models of cone receptor activity. In addition, alternative models of human cone receptor adaptation will be tested. Second, the long term goal of the proposed research is a quantitative model of the human ERG useful for testing hypotheses about normal and abnormal retinal activity. Thus, we propose to develop a model of the human ERG that encompasses the activity of the inner nuclear layer as well as the receptors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY009076-02
Application #
3266445
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1991-05-01
Project End
1994-04-30
Budget Start
1992-05-01
Budget End
1993-04-30
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
Other Domestic Higher Education
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027

  Publications

Duncker, Tobias; Lee, Winston; Jiang, Fan et al. (2018) ACUTE ZONAL OCCULT OUTER RETINOPATHY: Structural and Functional Analysis Across the Transition Zone Between Healthy and Diseased Retina. Retina 38:118-127
Daiger, Stephen P; Bowne, Sara J; Sullivan, Lori S et al. (2018) Molecular Findings in Families with an Initial Diagnose of Autosomal Dominant Retinitis Pigmentosa (adRP). Adv Exp Med Biol 1074:237-245
Soens, Zachry T; Branch, Justin; Wu, Shijing et al. (2017) Leveraging splice-affecting variant predictors and a minigene validation system to identify Mendelian disease-causing variants among exon-captured variants of uncertain significance. Hum Mutat 38:1521-1533
Jones, Kaylie D; Wheaton, Dianna K; Bowne, Sara J et al. (2017) Next-generation sequencing to solve complex inherited retinal dystrophy: A case series of multiple genes contributing to disease in extended families. Mol Vis 23:470-481
Bennett, Lea D; Klein, Martin; Locke, Kirsten G et al. (2017) Dark-Adapted Chromatic Perimetry for Measuring Rod Visual Fields in Patients with Retinitis Pigmentosa. Transl Vis Sci Technol 6:15
Greenstein, Vivienne C; Nunez, Jason; Lee, Winston et al. (2017) A Comparison of En Face Optical Coherence Tomography and Fundus Autofluorescence in Stargardt Disease. Invest Ophthalmol Vis Sci 58:5227-5236
Verdina, Tommaso; Greenstein, Vivienne C; Sodi, Andrea et al. (2017) Multimodal analysis of the Preferred Retinal Location and the Transition Zone in patients with Stargardt Disease. Graefes Arch Clin Exp Ophthalmol 255:1307-1317
Hariri, Amir H; Zhang, Hong Yang; Ho, Alexander et al. (2016) Quantification of Ellipsoid Zone Changes in Retinitis Pigmentosa Using en Face Spectral Domain-Optical Coherence Tomography. JAMA Ophthalmol 134:628-35
Ramachandran, Rithambara; X Cai, Cindy; Lee, Dongwon et al. (2016) Reliability of a Manual Procedure for Marking the EZ Endpoint Location in Patients with Retinitis Pigmentosa. Transl Vis Sci Technol 5:6
Sadda, SriniVas R; Chakravarthy, Usha; Birch, David G et al. (2016) CLINICAL ENDPOINTS FOR THE STUDY OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION. Retina 36:1806-22

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