Abstract

The primary goal of this project is to uncover physiological and anatomical correlates of amblyopia in both humans and monkeys. This will continue the P.I.'s previous grant concerning the structure of ocular dominance columns (ODC) in animals and humans. There are 5 new specific aims that he will investigate: (1) The effect of strabismus on periodicity of ocular dominance columns, (2) Possible disruption of intrinsic connections from layer 4C to layer 3 in V1, (3) Alterations in human amblyopes of the complete pattern of ODC's, the organization of CO stripes in V2, and the organization of other extrastriate visual areas, (4) the cortical locus of visual suppression in strabismus and (5) the identity of a visual area anterior to macaque dorsal V2 that contains a unique CO pattern. Together, these new experiments will extend the previous work by investigating mechanisms beyond the ODC's that might be responsible for the poor vision in amblyopia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY010217-08
Application #
6179978
Study Section
Visual Sciences B Study Section (VISB)
Program Officer
Oberdorfer, Michael
Project Start
1993-07-01
Project End
2003-06-30
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
8
Fiscal Year
2000
Total Cost
$311,004
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Adams, Daniel L; Rapone, Brittany C; Economides, John R et al. (2018) Spontaneous Reattachment of the Medial Rectus After Free Tenotomy. J Pediatr Ophthalmol Strabismus 55:335-338
Economides, John R; Rapone, Brittany C; Adams, Daniel L et al. (2018) Normal Topography and Binocularity of the Superior Colliculus in Strabismus. J Neurosci 38:173-182
Economides, John R; Adams, Daniel L; Horton, Jonathan C (2017) Capturing the Moment of Fusion Loss in Intermittent Exotropia. Ophthalmology 124:496-504
Horton, Jonathan C (2017) Invited Commentary: Ganglion Cell Complex Measurement in Compressive Optic Neuropathy. J Neuroophthalmol 37:13-15
Horton, Jonathan C; Barkovich, A James (2017) Bilateral Optic Disc Pits With Posterior Pituitary Ectopia. J Neuroophthalmol 37:401-402
Horton, Jonathan C; Fahle, Manfred; Mulder, Theo et al. (2017) Adaptation, perceptual learning, and plasticity of brain functions. Graefes Arch Clin Exp Ophthalmol 255:435-447
Adams, Daniel L; Economides, John R; Horton, Jonathan C (2017) Incomitance and Eye Dominance in Intermittent Exotropia. Invest Ophthalmol Vis Sci 58:4049-4055
Economides, John R; Adams, Daniel L; Horton, Jonathan C (2016) Normal correspondence of tectal maps for saccadic eye movements in strabismus. J Neurophysiol 116:2541-2549
Adams, Daniel L; Economides, John R; Horton, Jonathan C (2016) Cortical Representation of a Myopic Peripapillary Crescent. Ophthalmology 123:1494-9
Economides, John R; Adams, Daniel L; Horton, Jonathan C (2016) Variability of Ocular Deviation in Strabismus. JAMA Ophthalmol 134:63-9

Showing the most recent 10 out of 63 publications