Abstract

The Principal Investigator proposes to continue a prospective epidemiological study of HIV-1-associated CMV retinitis (CMVR).
The specific aims of the original research included determining the incidence of resistant CMV, the risk factors for development of resistance, and the relationship between resistance and clinical outcome. This research will expand upon the prior Aims by evaluating plasma CMV DNA viral load as a means of identifying patients who harbor resistant virus, evaluating direct plasma screening for UL97 mutations to identify rapidly patients with ganciclovir-resistant CMV, and comparing ganciclovir resistance mutations between vitreous, blood, and urine samples.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY010268-07
Application #
2888433
Study Section
AIDS and Related Research Study Section 7 (ARRG)
Project Start
1993-07-01
Project End
2003-07-31
Budget Start
1999-08-01
Budget End
2000-07-31
Support Year
7
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Jabs, Douglas A (2011) Cytomegalovirus retinitis and the acquired immunodeficiency syndrome--bench to bedside: LXVII Edward Jackson Memorial Lecture. Am J Ophthalmol 151:198-216.e1
Jabs, Douglas A; Martin, Barbara K; Forman, Michael S et al. (2010) Mortality associated with resistant cytomegalovirus among patients with cytomegalovirus retinitis and AIDS. Ophthalmology 117:128-132.e2
Martin, Barbara K; Ricks, Michelle O; Forman, Michael S et al. (2007) Change over time in incidence of ganciclovir resistance in patients with cytomegalovirus retinitis. Clin Infect Dis 44:1001-8
Jabs, Douglas A; Martin, Barbara K; Ricks, Michelle O et al. (2006) Detection of ganciclovir resistance in patients with AIDS and cytomegalovirus retinitis: correlation of genotypic methods with viral phenotype and clinical outcome. J Infect Dis 193:1728-37
Jabs, Douglas A; Martin, Barbara K; Forman, Michael S et al. (2005) Cytomegalovirus (CMV) blood DNA load, CMV retinitis progression, and occurrence of resistant CMV in patients with CMV retinitis. J Infect Dis 192:640-9
Kempen, John H; Jabs, Douglas A; Wilson, Laura A et al. (2005) Incidence of cytomegalovirus (CMV) retinitis in second eyes of patients with the acquired immune deficiency syndrome and unilateral CMV retinitis. Am J Ophthalmol 139:1028-34
Jabs, Douglas A (2004) AIDS and ophthalmology in 2004. Arch Ophthalmol 122:1040-2
Hubbard, Larry D; Ricks, Michelle O; Martin, Barbara K et al. (2004) Comparability of two fundus photograph reading centers in grading cytomegalovirus retinitis progression. Am J Ophthalmol 137:426-34
Tanna, Angelo P; Kempen, John H; Dunn, James P et al. (2003) Incidence and management of cataract after retinal detachment repair with silicone oil in immune compromised patients with cytomegalovirus retinitis. Am J Ophthalmol 136:1009-15
Jabs, Douglas A; Martin, Barbara K; Forman, Michael S et al. (2003) Cytomegalovirus resistance to ganciclovir and clinical outcomes of patients with cytomegalovirus retinitis. Am J Ophthalmol 135:26-34

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