Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY010589-03
Application #
2164571
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1994-06-01
Project End
1997-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Rosalind Franklin University
Department
Physiology
Type
Schools of Medicine
DUNS #
069501252
City
North Chicago
State
IL
Country
United States
Zip Code
60064
Tong, Jun-Jie; Minogue, Peter J; Kobeszko, Matthew et al. (2015) The connexin46 mutant, Cx46T19M, causes loss of gap junction function and alters hemi-channel gating. J Membr Biol 248:145-55
Ebihara, Lisa; Korzyukov, Yegor; Kothari, Sorabh et al. (2014) Cx46 hemichannels contribute to the sodium leak conductance in lens fiber cells. Am J Physiol Cell Physiol 306:C506-13
Tong, Jun-Jie; Sohn, Bonnie C H; Lam, Anh et al. (2013) Properties of two cataract-associated mutations located in the NH2 terminus of connexin 46. Am J Physiol Cell Physiol 304:C823-32
Beyer, Eric C; Ebihara, Lisa; Berthoud, Viviana M (2013) Connexin mutants and cataracts. Front Pharmacol 4:43
Ebihara, Lisa; Tong, Jun-Jie; Vertel, Barbara et al. (2011) Properties of connexin 46 hemichannels in dissociated lens fiber cells. Invest Ophthalmol Vis Sci 52:882-9
Tong, Jun-Jie; Minogue, Peter J; Guo, Wenji et al. (2011) Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50. Am J Physiol Cell Physiol 300:C1055-64
Minogue, Peter J; Tong, Jun-Jie; Arora, Anita et al. (2009) A mutant connexin50 with enhanced hemichannel function leads to cell death. Invest Ophthalmol Vis Sci 50:5837-45
Graw, Jochen; Schmidt, Werner; Minogue, Peter J et al. (2009) The GJA8 allele encoding CX50I247M is a rare polymorphism, not a cataract-causing mutation. Mol Vis 15:1881-5
Arora, A; Minogue, P J; Liu, X et al. (2008) A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts. J Med Genet 45:155-60
Chung, June; Berthoud, Viviana M; Novak, Layne et al. (2007) Transgenic overexpression of connexin50 induces cataracts. Exp Eye Res 84:513-28

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