Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
1R01EY011388-01
Application #
2165713
Study Section
Visual Sciences C Study Section (VISC)
Project Start
1996-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Florida
Department
Neurosciences
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Semple-Rowland, Susan L; Berry, Jonathan (2014) Use of lentiviral vectors to deliver and express bicistronic transgenes in developing chicken embryos. Methods 66:466-73
Semple-Rowland, Susan; Madorsky, Irina; Bolch, Susan et al. (2013) Activation of phospholipase C mimics the phase shifting effects of light on melatonin rhythms in retinal photoreceptors. PLoS One 8:e83378
Verrier, Jonathan D; Madorsky, Irina; Coggin, William E et al. (2011) Bicistronic lentiviruses containing a viral 2A cleavage sequence reliably co-express two proteins and restore vision to an animal model of LCA1. PLoS One 6:e20553
Semple-Rowland, Susan L; Coggin, William E; Geesey, Mero et al. (2010) Expression characteristics of dual-promoter lentiviral vectors targeting retinal photoreceptors and Müller cells. Mol Vis 16:916-34
Semple-Rowland, Susan L; Eccles, Kristofer S; Humberstone, Elizabeth J (2007) Targeted expression of two proteins in neural retina using self-inactivating, insulated lentiviral vectors carrying two internal independent promoters. Mol Vis 13:2001-11
Haire, Shannon E; Pang, Jijing; Boye, Sanford L et al. (2006) Light-driven cone arrestin translocation in cones of postnatal guanylate cyclase-1 knockout mouse retina treated with AAV-GC1. Invest Ophthalmol Vis Sci 47:3745-53
Williams, Melissa L; Coleman, Jason E; Haire, Shannon E et al. (2006) Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness. PLoS Med 3:e201
Zhang, Yan; Semple-Rowland, Susan L (2005) Rhythmic expression of clock-controlled genes in retinal photoreceptors is sensitive to 18-beta-glycyrrhetnic acid and 18-alpha-glycyrrhetnic acid-3-hemisuccinate. Brain Res Mol Brain Res 135:30-9
Coleman, Jason E; Semple-Rowland, Susan L (2005) GC1 deletion prevents light-dependent arrestin translocation in mouse cone photoreceptor cells. Invest Ophthalmol Vis Sci 46:12-6
Coleman, Jason E; Wu, Kebin; Fulle, Hans Jurgen et al. (2004) The 5' flanking sequence of the human retGC1 gene acquires a photoreceptor cell restricted activity pattern over the course of retinal development. Mol Vis 10:720-7

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