Patients with HIV-disease continue to be treated with highly activated antiretroviral therapy (HAART). However, our research group and others have shown that vision loss and neurological loss continues to occur despite elevated CD4 counts. We have previously shown that we are able to visualize subtle retinal changes associated with healed cotton-wool spots (CWS) up to 16 years after the active phase. In this grant we plan to study the group of subjects that continue to exhibit neurological changes and retinal damage. Our hypothesis is that retinal damage is associated with neurological changes. Our first specific aim is to quantify retinal damage by high-resolution adaptive- optical corrected OCT. Our second specific aim is to develop a computer algorithm to map the defects associated with healed CWS. Our results have indicated that healed CWS demonstrate a characteristic restructuring of the retinal layers. This restructuring can be mapped in 3-D OCT images. The third specific aim is to correlate structural retinal defects with neurological markers collected by our collaborators at the UCSD's HIV Neurobehavioral Research Center. A possible correlation might help us by using retinal structural markers as indicators for neurological damage. Our team of collaborators includes experts on retinal imaging, computer processing, and neurobehavioral research.

Public Health Relevance

This grant will create a method of automatically mapping the presence of retinal damage associated with HIV infection. A high-resolution eye camera will be used to systematically image the back of the eye. The study will compare structural information to functional information to find a possible correlation.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
2R01EY016323-06
Application #
8154961
Study Section
Special Emphasis Panel (ZRG1-AARR-K (03))
Program Officer
Mckie, George Ann
Project Start
2004-12-01
Project End
2014-08-31
Budget Start
2011-09-30
Budget End
2012-08-31
Support Year
6
Fiscal Year
2011
Total Cost
$574,224
Indirect Cost
Name
University of California San Diego
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Ramkumar, Hema L; Nguyen, Brian; Bartsch, Dirk-Uwe et al. (2018) REDUCED GANGLION CELL VOLUME ON OPTICAL COHERENCE TOMOGRAPHY IN PATIENTS WITH GEOGRAPHIC ATROPHY. Retina 38:2159-2167
Bosse, Brandon; Damle, Samir; Akinin, Abraham et al. (2018) In Vivo Photovoltaic Performance of a Silicon Nanowire Photodiode-Based Retinal Prosthesis. Invest Ophthalmol Vis Sci 59:5885-5892
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Muftuoglu, Ilkay Kilic; Ramkumar, Hema L; Bartsch, Dirk-Uwe et al. (2018) QUANTITATIVE ANALYSIS OF THE INNER RETINAL LAYER THICKNESSES IN AGE-RELATED MACULAR DEGENERATION USING CORRECTED OPTICAL COHERENCE TOMOGRAPHY SEGMENTATION. Retina 38:1478-1484
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Kilic Muftuoglu, Ilkay; Bartsch, Dirk-Uwe; Barteselli, Giulio et al. (2018) VISUALIZATION OF MACULAR PUCKER BY MULTICOLOR SCANNING LASER IMAGING. Retina 38:352-358
Muftuoglu, Ilkay Kilic; Gaber, Raouf; Bartsch, Dirk-Uwe et al. (2018) Comparison of conventional color fundus photography and multicolor imaging in choroidal or retinal lesions. Graefes Arch Clin Exp Ophthalmol 256:643-649
Muftuoglu, Ilkay K; Alam, Mostafa; You, Qi Sheng et al. (2017) Reply. Retina 37:e110-e112
Bartsch, Dirk-Uwe; Muftuoglu, Ilkay K; Freeman, William R (2016) Laser Pointers Revisited. Retina 36:1611-3
Barteselli, Giulio; Bartsch, Dirk-Uwe; Weinreb, Robert N et al. (2016) REAL-TIME FULL-DEPTH VISUALIZATION OF POSTERIOR OCULAR STRUCTURES: Comparison Between Full-Depth Imaging Spectral Domain Optical Coherence Tomography and Swept-Source Optical Coherence Tomography. Retina 36:1153-61

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