Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM004842-40
Application #
2166063
Study Section
Biochemistry Study Section (BIO)
Project Start
1978-09-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
40
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cornell University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Lewis, Ryan W; Hess, George P; Ganem, Bruce (2011) Use of multicomponent reactions in developing small-molecule tools to study GABAA receptor mechanism and function. Future Med Chem 3:243-50
Ramakrishnan, Latha; Hess, George P (2010) Mechanism of potentiation of a dysfunctional epilepsy-linked mutated GABA(A) receptor by a neurosteroid (3alpha, 21-dihydroxy-5alpha-pregnan-20-one): transient kinetic investigations. Biochemistry 49:7892-901
Fan, Lijun; Lewis, Ryan W; Hess, George P et al. (2009) A new synthesis of caged GABA compounds for studying GABAA receptors. Bioorg Med Chem Lett 19:3932-3
Shembekar, Vishakha R; Chen, Yongli; Carpenter, Barry K et al. (2007) Coumarin-caged glycine that can be photolyzed within 3 microseconds by visible light. Biochemistry 46:5479-84
Krivoshein, Arcadius V; Hess, George P (2006) On the mechanism of alleviation by phenobarbital of the malfunction of an epilepsy-linked GABA(A) receptor. Biochemistry 45:11632-41
Shembekar, Vishakha R; Chen, Yongli; Carpenter, Barry K et al. (2005) A protecting group for carboxylic acids that can be photolyzed by visible light. Biochemistry 44:7107-14
Ramakrishnan, Latha; Hess, George P (2004) On the mechanism of a mutated and abnormally functioning gamma-aminobutyric acid (A) receptor linked to epilepsy. Biochemistry 43:7534-40
Wieboldt, Raymond; Ramesh, Doraiswamy; Jabri, Evelyn et al. (2002) Synthesis and characterization of photolabile o-nitrobenzyl derivatives of urea. J Org Chem 67:8827-31
Breitinger, H G; Geetha, N; Hess, G P (2001) Inhibition of the serotonin 5-HT3 receptor by nicotine, cocaine, and fluoxetine investigated by rapid chemical kinetic techniques. Biochemistry 40:8419-29
Xia, Q; Ganem, B (2001) Asymmetric total synthesis of (-)-alpha-kainic acid using an enantioselective, metal-promoted ene cyclization. Org Lett 3:485-7

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